The authors used a thermoregulation paradigm to test the hypothesis that chronic treatment with bright artificial light produces subsensitivity to the hypothermic effects of clonidine, an [alpha]2-agonist. One week of treatment produced blunting of the hypothermic response to clonidine (p 2-receptor.
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http://deepblue.lib.umich.edu/bitstream/2027.42/27582/1/0000626.pdf