| dc.contributor |
Division of Nuclear Medicine, University of Michigan Medical Center, 1500 East Medical Center Drive, 48109-0028, Ann Arbor, MI, USA |
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| dc.contributor |
Division of Nuclear Medicine, University of Michigan Medical Center, 1500 East Medical Center Drive, 48109-0028, Ann Arbor, MI, USA |
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| dc.contributor |
Division of Nuclear Medicine, University of Michigan Medical Center, 1500 East Medical Center Drive, 48109-0028, Ann Arbor, MI, USA |
|
| dc.contributor |
Department of Pathology, Ann Arbor, Michigan, USA |
|
| dc.contributor |
Ann Arbor |
|
| dc.creator |
Liebert, Monica |
|
| dc.creator |
Beierwaltes, William H. |
|
| dc.creator |
Wilson, Barry S. |
|
| dc.creator |
Wahl, Richard L. |
|
| dc.date |
2006-09-11T18:17:02Z |
|
| dc.date |
2006-09-11T18:17:02Z |
|
| dc.date |
1987-06 |
|
| dc.date.accessioned |
2022-05-19T11:34:36Z |
|
| dc.date.available |
2022-05-19T11:34:36Z |
|
| dc.identifier |
Wahl, Richard L.; Wilson, Barry S.; Liebert, Monica; Beierwaltes, William H.; (1987). "High-dose, unlabeled, nonspecific antibody pretreatment: influence on specific antibody localization to human melanoma xenografts." Cancer Immunology Immunotherapy 24(3): 221-224. <http://hdl.handle.net/2027.42/46853> |
|
| dc.identifier |
1432-0851 |
|
| dc.identifier |
0340-7004 |
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| dc.identifier |
https://hdl.handle.net/2027.42/46853 |
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| dc.identifier |
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3594484&dopt=citation |
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| dc.identifier |
3594484 |
|
| dc.identifier |
http://dx.doi.org/10.1007/BF00205633 |
|
| dc.identifier |
Cancer Immunology Immunotherapy |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/105541 |
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| dc.description |
Nonspecific uptake of radiolabeled monoclonal antibodies in normal tissues is a significant problem for tumor imaging. A potential means of decreasing nonspecific antibody binding is to “blockade” nonspecific antibody binding sites by predosing with cold, nonspecific isotypematched antibody, before injecting specific antibody. Nontumor-specific murine monoclonal antibody LK2H10 (IgG1) or Ab-1 (IgG2a) was given i.v. at doses of 0 to 3.5 mg to nude mice with xenografts of human melanoma. These mice were then given i.v. 4 μg of 131 I anti-high molecular weight antigen of melanoma (HMWMAA) monoclonal antibody 763.24T (IgG1) or 225.28S (IgG2a), respectively. These mice were also given a tracer dose of 125 I LK2H10 or Ab-1, respectively. Specific tumor uptake of anti-HMWMAA antibodies was see in all cases. No drop in tumor or nontumor uptake was demonstrated for either of the tumor-specific or nonspecific monoclonal antibodies due to nonspecific monoclonal antibody pretreatment. These data suggest that high doses of isotype-matched unlabeled nonspecific monoclonal antibody given before 131 I tumor-specific monoclonal antibody, will not enhance tumor imaging. |
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| dc.description |
Peer Reviewed |
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| dc.description |
http://deepblue.lib.umich.edu/bitstream/2027.42/46853/1/262_2004_Article_BF00205633.pdf |
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| dc.format |
429299 bytes |
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| dc.format |
3115 bytes |
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| dc.format |
application/pdf |
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| dc.format |
text/plain |
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| dc.format |
application/pdf |
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| dc.language |
en_US |
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| dc.publisher |
Springer-Verlag |
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| dc.subject |
Oncology |
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| dc.subject |
Cancer Research |
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| dc.subject |
Biomedicine |
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| dc.subject |
Immunology |
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| dc.subject |
Microbiology and Immunology |
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| dc.subject |
Biological Chemistry |
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| dc.subject |
Science |
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| dc.subject |
Health Sciences |
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| dc.title |
High-dose, unlabeled, nonspecific antibody pretreatment: influence on specific antibody localization to human melanoma xenografts |
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| dc.type |
Article |
|