| dc.contributor |
From: Hypertension Research, Department of Internal Medicine, University of Michigan, Ann Arbor, USA |
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| dc.creator |
Hunyor, Stephen N. |
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| dc.creator |
Zweifler, Andrew J. |
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| dc.creator |
Hansson, Lennart |
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| dc.creator |
Schork, M. Anthony |
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| dc.creator |
Ellis, Charles N. |
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| dc.date |
2010-06-01T20:17:33Z |
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| dc.date |
2010-06-01T20:17:33Z |
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| dc.date |
1975-02 |
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| dc.date.accessioned |
2022-05-19T12:40:57Z |
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| dc.date.available |
2022-05-19T12:40:57Z |
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| dc.identifier |
Hunyor, Stephen N.; Zweifler, Andrew J.; Hansson, Lennart; Schork, M. Anthony; Ellis, Charles (1975). "Effect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma Volume." Internal Medicine Journal 5(1): 17-24. <http://hdl.handle.net/2027.42/73411> |
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| dc.identifier |
1444-0903 |
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| dc.identifier |
1445-5994 |
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| dc.identifier |
https://hdl.handle.net/2027.42/73411 |
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| dc.identifier |
10.1111/j.1445-5994.1975.tb03249.x |
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| dc.identifier |
Internal Medicine Journal |
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| dc.identifier |
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Crane, M. G., Harris, J. J. and Johns, V. J. ( 1972 ): Hyporeninemic hypertension, Amer. J. Med., 52, 457. |
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| dc.identifier |
Carey, R. M., Douglas, J. G., Schweikert, J. R. and Liddle, G. W. ( 1972 ): The syndrome of essential hypertension and suppressed plasma renin activity. Arch, intern. Med., 130, 849. |
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| dc.identifier |
Adlin, E. V., Marks, A. D. and Channick, B. J. ( 1972 ): Spironolactone and hydrochlorothiazide in essential hypertension, Arch, intern. Med., 130, 855. |
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| dc.identifier |
Woods, J. W., Liddle, G. W., Stant, E. G., Michelakis, A. M. and Brill, A. B. ( 1969 ): Effect of an adrenal inhibitor in hypertensive patients with suppressed renin, Arch, intern. Med., 120, 366. |
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| dc.identifier |
Jose, A., Crout, J. R. and Kaplan, N. M. ( 1970 ): Suppressed plasma renin activity in essential hypertension, Ann. intern, Med., 72, 9. |
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| dc.identifier |
Valghan, E. D. Jr., Laragh, J. H., Gavras, I., Bchler, F. R., Gavras, H., Brunner, H. R. and Baer, L. ( 1973 ): Volume factors in low and normal rernin essential hypertension, Amer. J. Cardiol, 32, 523. |
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| dc.identifier |
Grim, C. E. and Peters, T. J. ( 1971 ): Low renin hypertension: A state of inappropriate secretion of aldosterone ? Circulation 44, ( Suppl. II ), 172. |
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| dc.identifier |
KÜchel, O., Cuche, J. L., Barbeau, A., Hamet, P., Boucher, R., Nowaczynski, W. and Genest, J. ( 1970 ): Low renin hypertension and beta-adrenergic hyperreactivity. two extreme poles of “essential” hypertension, Circulation 42, ( Suppl. III ), 70. |
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Gwinup, G. and Steinberg, T. ( 1967 ): Differentia! response to thiazide and spironolactone in primary aldosteronism, Arch, intern. Med., 120, 436. |
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Julius, S., Pascual, A. V., Reilly, K. and London, R. ( 1971 ): Abnormalities of plasma volume in borderline hypertension. Arch, intern. Med., 127, 116. |
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Haber, E., Koerner, T., Page, L. B., Kliman, B. and Purnode, A. ( 1969 ): Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects, J. clin. Endocr., 29, 1349. |
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| dc.identifier |
Black, Susanne J. ( 1972 ): Personal communication, Searle Labs., Chicago, Ill. |
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KÜchel, O., Fishman, L. M., Liddle, G. W. and Michelakis, A. M. ( 1967 ): Effect of diazoxide on plasma renin activity in hypertensive patients, Ann. intern. Med., 67, 791. |
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Channick, B. J., Adlin, E. V. and Marks, A. D. ( 1969 ): Suppressed plasma renin activity in hypertension. Arch, intern. Med., 123, 131. |
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Helmer, O. M. ( 1969 ): Renin activity in blood from patients with hypertension, Canad. med. Ass. J., 90, 221. |
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| dc.identifier |
Creditor, M. C. and Loschky, U. K. ( 1967 ): Plasma renin activity in hypertension, Amer. J. Med., 43, 371. |
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Weinberger, M. H., Dowdy, A. J., Nokes, G. W. and Leutscher, J. A. ( 1968 ): Plasma renin activity and aldosterone secretion in hypertensive patients during high and low sodium intake and administration of diuretic, J. clin. Endocr., 28, 359. |
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| dc.identifier |
Fishman, L. M., KÜchel, O., Liddle, G. W., Michelakis, A. M., Gordon, R. D. and Chick, W. T. ( 1968 ): Incidence of primary-aidosteronism in uncomplicated “essential” hypertension: A prospective study with elevated aldosterone secretion and suppressed plasma renin activity used as diagnostic criteria, J. Amer. med. Ass., 205, 497. |
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| dc.identifier |
Tarazi, R. C., Frohlich, E. D. and Dustan, H. P. ( 1968 ): Plasma volume in men with essential hypertension, New. Engl. J. Med., 278, 762. |
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| dc.identifier |
Hunyor, S. N., Zweifler, A. J. and Hansson, L. ( 1973 ): Effect of spironolactone and chlorthalid one in essential hypertension: relation to plasma renin activity and plasma volume, Circulation., 48, ( Suppl. IV ), 83. |
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| dc.identifier |
Beevers, D. G., Brown, J. J., Ferris, J. B., Fraser, R., Lever, A. F. and Robertson, J. I. S. ( 1973 ): The use of spironolactone in the diagnosis and the treatment of hypertension associated with mineralocorticoid excess, Amer. Heart J., 86, 404. |
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| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/112238 |
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| dc.description |
The effect on blood pressure of high (400 mg/day-S400) and moderate dose (200 mg/day-S200) spironolactone and chlorthalidone (100 mg/day—C100), given in a random double-blind manner was related to plasma renin activity and plasma volume in 38 essential hypertensives. The fall in pressure from a control of 154/103 mm Hg was essentially the same after four weeks of each drug—S400 ABP 24/13 mm, S200 18/9 mm, C100 17/12 mm (all P < 0–001). Twelve of 37 patients (32%) had low initial renin, but this appeared as responsive to the chlorthalidone stimulus as that of the normal renin group. The anti-hypertensive effect of all regimens was unrelated to plasma renin activity. Plasma volume was significantly lowered at the end of each treatment period, but the decline could not be correlated with blood pressure effects. Patients with initially low plasma volume were more likely to respond to S400 ( r = 0.545, P < 0.01), whereas the anti-hypertensive effect of the S200 and C100 regimens was independent of this variable. |
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| dc.description |
Peer Reviewed |
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| dc.description |
http://deepblue.lib.umich.edu/bitstream/2027.42/73411/1/j.1445-5994.1975.tb03249.x.pdf |
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| dc.format |
667769 bytes |
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3109 bytes |
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| dc.format |
application/pdf |
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| dc.format |
text/plain |
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| dc.format |
application/pdf |
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| dc.publisher |
Blackwell Publishing Ltd |
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| dc.rights |
1975 Published on behalf of the Adult Medicine Division of the Royal Australasian College of Physicians |
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| dc.subject |
Internal Medicine and Specialties |
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| dc.subject |
Health Sciences |
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| dc.title |
Effect of High Dose Spironolactone and Chlorthalidone in Essential Hypertension: Relation to Plasma Renin Activity and Plasma Volume |
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| dc.type |
Article |
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