Sangam: A Confluence of Knowledge Streams

Shared genetic risk between eating disorder- and substance- use- related phenotypes: Evidence from genome- wide association studies

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dc.creator Munn‐chernoff, Melissa A.
dc.creator Johnson, Emma C.
dc.creator Chou, Yi‐ling
dc.creator Coleman, Jonathan R.I.
dc.creator Thornton, Laura M.
dc.creator Walters, Raymond K.
dc.creator Yilmaz, Zeynep
dc.creator Baker, Jessica H.
dc.creator Hübel, Christopher
dc.creator Gordon, Scott
dc.creator Medland, Sarah E.
dc.creator Watson, Hunna J.
dc.creator Gaspar, Héléna A.
dc.creator Bryois, Julien
dc.creator Hinney, Anke
dc.creator Leppä, Virpi M.
dc.creator Mattheisen, Manuel
dc.creator Ripke, Stephan
dc.creator Yao, Shuyang
dc.creator Giusti‐rodríguez, Paola
dc.creator Hanscombe, Ken B.
dc.creator Adan, Roger A.H.
dc.creator Alfredsson, Lars
dc.creator Ando, Tetsuya
dc.creator Andreassen, Ole A.
dc.creator Berrettini, Wade H.
dc.creator Boehm, Ilka
dc.creator Boni, Claudette
dc.creator Boraska Perica, Vesna
dc.creator Buehren, Katharina
dc.creator Burghardt, Roland
dc.creator Cassina, Matteo
dc.creator Cichon, Sven
dc.creator Clementi, Maurizio
dc.creator Cone, Roger D.
dc.creator Courtet, Philippe
dc.creator Crow, Scott
dc.creator Crowley, James J.
dc.creator Danner, Unna N.
dc.creator Davis, Oliver S.P.
dc.creator Zwaan, Martina
dc.creator Dedoussis, George
dc.creator Degortes, Daniela
dc.creator DeSocio, Janiece E.
dc.creator Dick, Danielle M.
dc.creator Dikeos, Dimitris
dc.creator Dina, Christian
dc.creator Dmitrzak‐weglarz, Monika
dc.creator Docampo, Elisa
dc.creator Duncan, Laramie E.
dc.creator Egberts, Karin
dc.creator Ehrlich, Stefan
dc.creator Escaramís, Geòrgia
dc.creator Esko, Tõnu
dc.creator Estivill, Xavier
dc.creator Farmer, Anne
dc.creator Favaro, Angela
dc.creator Fernández‐aranda, Fernando
dc.creator Fichter, Manfred M.
dc.creator Fischer, Krista
dc.creator Föcker, Manuel
dc.creator Foretova, Lenka
dc.creator Forstner, Andreas J.
dc.creator Forzan, Monica
dc.creator Franklin, Christopher S.
dc.creator Gallinger, Steven
dc.creator Giegling, Ina
dc.creator Giuranna, Johanna
dc.creator Gonidakis, Fragiskos
dc.creator Gorwood, Philip
dc.creator Gratacos Mayora, Monica
dc.creator Guillaume, Sébastien
dc.creator Guo, Yiran
dc.creator Hakonarson, Hakon
dc.creator Hatzikotoulas, Konstantinos
dc.creator Hauser, Joanna
dc.creator Hebebrand, Johannes
dc.creator Helder, Sietske G.
dc.creator Herms, Stefan
dc.creator Herpertz‐dahlmann, Beate
dc.creator Herzog, Wolfgang
dc.creator Huckins, Laura M.
dc.creator Hudson, James I.
dc.creator Imgart, Hartmut
dc.creator Inoko, Hidetoshi
dc.creator Janout, Vladimir
dc.creator Jiménez‐murcia, Susana
dc.creator Julià, Antonio
dc.creator Kalsi, Gursharan
dc.creator Kaminská, Deborah
dc.creator Karhunen, Leila
dc.creator Karwautz, Andreas
dc.creator Kas, Martien J.H.
dc.creator Kennedy, James L.
dc.creator Keski‐rahkonen, Anna
dc.creator Kiezebrink, Kirsty
dc.creator Kim, Youl‐ri
dc.creator Klump, Kelly L.
dc.creator Knudsen, Gun Peggy S.
dc.creator La Via, Maria C.
dc.creator Le Hellard, Stephanie
dc.creator Levitan, Robert D.
dc.creator Li, Dong
dc.creator Lilenfeld, Lisa
dc.creator Lin, Bochao Danae
dc.creator Lissowska, Jolanta
dc.creator Luykx, Jurjen
dc.creator Magistretti, Pierre J.
dc.creator Maj, Mario
dc.creator Mannik, Katrin
dc.creator Marsal, Sara
dc.creator Marshall, Christian R.
dc.creator Mattingsdal, Morten
dc.creator McDevitt, Sara
dc.creator McGuffin, Peter
dc.creator Metspalu, Andres
dc.creator Meulenbelt, Ingrid
dc.creator Micali, Nadia
dc.creator Mitchell, Karen
dc.creator Monteleone, Alessio Maria
dc.creator Monteleone, Palmiero
dc.creator Nacmias, Benedetta
dc.creator Navratilova, Marie
dc.creator Ntalla, Ioanna
dc.creator O’Toole, Julie K.
dc.creator Ophoff, Roel A.
dc.creator Padyukov, Leonid
dc.creator Palotie, Aarno
dc.creator Pantel, Jacques
dc.creator Papezova, Hana
dc.creator Pinto, Dalila
dc.creator Rabionet, Raquel
dc.creator Raevuori, Anu
dc.creator Ramoz, Nicolas
dc.creator Reichborn‐kjennerud, Ted
dc.creator Ricca, Valdo
dc.creator Ripatti, Samuli
dc.creator Ritschel, Franziska
dc.creator Roberts, Marion
dc.creator Rotondo, Alessandro
dc.creator Rujescu, Dan
dc.creator Rybakowski, Filip
dc.creator Santonastaso, Paolo
dc.creator Scherag, André
dc.creator Scherer, Stephen W.
dc.creator Schmidt, Ulrike
dc.creator Schork, Nicholas J.
dc.creator Schosser, Alexandra
dc.creator Seitz, Jochen
dc.creator Slachtova, Lenka
dc.creator Slagboom, P. Eline
dc.creator Slof‐op’T Landt, Margarita C.t.
dc.creator Slopien, Agnieszka
dc.creator Sorbi, Sandro
dc.creator Świątkowska, Beata
dc.creator Szatkiewicz, Jin P.
dc.creator Tachmazidou, Ioanna
dc.creator Tenconi, Elena
dc.creator Tortorella, Alfonso
dc.creator Tozzi, Federica
dc.creator Treasure, Janet
dc.creator Tsitsika, Artemis
dc.creator Tyszkiewicz‐nwafor, Marta
dc.creator Tziouvas, Konstantinos
dc.creator Elburg, Annemarie A.
dc.creator Furth, Eric F.
dc.creator Wagner, Gudrun
dc.creator Walton, Esther
dc.creator Widen, Elisabeth
dc.creator Zeggini, Eleftheria
dc.creator Zerwas, Stephanie
dc.creator Zipfel, Stephan
dc.creator Bergen, Andrew W.
dc.creator Boden, Joseph M.
dc.creator Brandt, Harry
dc.creator Crawford, Steven
dc.creator Halmi, Katherine A.
dc.creator Horwood, L. John
dc.creator Johnson, Craig
dc.creator Kaplan, Allan S.
dc.creator Kaye, Walter H.
dc.creator Mitchell, James
dc.creator Olsen, Catherine M.
dc.creator Pearson, John F.
dc.creator Pedersen, Nancy L.
dc.creator Strober, Michael
dc.creator Werge, Thomas
dc.creator Whiteman, David C.
dc.creator Woodside, D. Blake
dc.creator Grove, Jakob
dc.creator Henders, Anjali K.
dc.creator Larsen, Janne T.
dc.creator Parker, Richard
dc.creator Petersen, Liselotte V.
dc.creator Jordan, Jennifer
dc.creator Kennedy, Martin A.
dc.creator Birgegård, Andreas
dc.creator Lichtenstein, Paul
dc.creator Norring, Claes
dc.creator Landén, Mikael
dc.creator Mortensen, Preben Bo
dc.creator Polimanti, Renato
dc.creator McClintick, Jeanette N.
dc.creator Adkins, Amy E.
dc.creator Aliev, Fazil
dc.creator Bacanu, Silviu‐alin
dc.creator Batzler, Anthony
dc.creator Bertelsen, Sarah
dc.creator Biernacka, Joanna M.
dc.creator Bigdeli, Tim B.
dc.creator Chen, Li‐shiun
dc.creator Clarke, Toni‐kim
dc.creator Degenhardt, Franziska
dc.creator Docherty, Anna R.
dc.creator Edwards, Alexis C.
dc.creator Foo, Jerome C.
dc.creator Fox, Louis
dc.creator Frank, Josef
dc.creator Hack, Laura M.
dc.creator Hartmann, Annette M.
dc.creator Hartz, Sarah M.
dc.creator Heilmann‐heimbach, Stefanie
dc.creator Hodgkinson, Colin
dc.creator Hoffmann, Per
dc.creator Hottenga, Jouke‐jan
dc.creator Konte, Bettina
dc.creator Lahti, Jari
dc.creator Lahti‐pulkkinen, Marius
dc.creator Lai, Dongbing
dc.creator Ligthart, Lannie
dc.creator Loukola, Anu
dc.creator Maher, Brion S.
dc.creator Mbarek, Hamdi
dc.creator McIntosh, Andrew M.
dc.creator McQueen, Matthew B.
dc.creator Meyers, Jacquelyn L.
dc.creator Milaneschi, Yuri
dc.creator Palviainen, Teemu
dc.creator Peterson, Roseann E.
dc.creator Ryu, Euijung
dc.creator Saccone, Nancy L.
dc.creator Salvatore, Jessica E.
dc.creator Sanchez‐roige, Sandra
dc.creator Schwandt, Melanie
dc.creator Sherva, Richard
dc.creator Streit, Fabian
dc.creator Strohmaier, Jana
dc.creator Thomas, Nathaniel
dc.creator Wang, Jen‐chyong
dc.creator Webb, Bradley T.
dc.creator Wedow, Robbee
dc.creator Wetherill, Leah
dc.creator Wills, Amanda G.
dc.creator Zhou, Hang
dc.creator Boardman, Jason D.
dc.creator Chen, Danfeng
dc.creator Choi, Doo‐sup
dc.creator Copeland, William E.
dc.creator Culverhouse, Robert C.
dc.creator Dahmen, Norbert
dc.creator Degenhardt, Louisa
dc.creator Domingue, Benjamin W.
dc.creator Frye, Mark A.
dc.creator Gäebel, Wolfgang
dc.creator Hayward, Caroline
dc.creator Ising, Marcus
dc.creator Keyes, Margaret
dc.creator Kiefer, Falk
dc.creator Koller, Gabriele
dc.creator Kramer, John
dc.creator Kuperman, Samuel
dc.creator Lucae, Susanne
dc.creator Lynskey, Michael T.
dc.creator Maier, Wolfgang
dc.creator Mann, Karl
dc.creator Männistö, Satu
dc.creator Müller‐myhsok, Bertram
dc.creator Murray, Alison D.
dc.creator Nurnberger, John I.
dc.creator Preuss, Ulrich
dc.creator Räikkönen, Katri
dc.creator Reynolds, Maureen D.
dc.creator Ridinger, Monika
dc.creator Scherbaum, Norbert
dc.creator Schuckit, Marc A.
dc.creator Soyka, Michael
dc.creator Treutlein, Jens
dc.creator Witt, Stephanie H.
dc.creator Wodarz, Norbert
dc.creator Zill, Peter
dc.creator Adkins, Daniel E.
dc.creator Boomsma, Dorret I.
dc.creator Bierut, Laura J.
dc.creator Brown, Sandra A.
dc.creator Bucholz, Kathleen K.
dc.creator Costello, E. Jane
dc.creator Wit, Harriet
dc.creator Diazgranados, Nancy
dc.creator Eriksson, Johan G.
dc.creator Farrer, Lindsay A.
dc.creator Foroud, Tatiana M.
dc.creator Gillespie, Nathan A.
dc.creator Goate, Alison M.
dc.creator Goldman, David
dc.creator Grucza, Richard A.
dc.creator Hancock, Dana B.
dc.creator Harris, Kathleen Mullan
dc.creator Hesselbrock, Victor
dc.creator Hewitt, John K.
dc.creator Hopfer, Christian J.
dc.creator Iacono, William G.
dc.creator Johnson, Eric O.
dc.creator Karpyak, Victor M.
dc.creator Kendler, Kenneth S.
dc.creator Kranzler, Henry R.
dc.creator Krauter, Kenneth
dc.creator Lind, Penelope A.
dc.creator McGue, Matt
dc.creator MacKillop, James
dc.creator Madden, Pamela A.F.
dc.creator Maes, Hermine H.
dc.creator Magnusson, Patrik K.E.
dc.creator Nelson, Elliot C.
dc.creator Nöthen, Markus M.
dc.creator Palmer, Abraham A.
dc.creator Penninx, Brenda W.J.H.
dc.creator Porjesz, Bernice
dc.creator Rice, John P.
dc.creator Rietschel, Marcella
dc.creator Riley, Brien P.
dc.creator Rose, Richard J.
dc.creator Shen, Pei‐hong
dc.creator Silberg, Judy
dc.creator Stallings, Michael C.
dc.creator Tarter, Ralph E.
dc.creator Vanyukov, Michael M.
dc.creator Vrieze, Scott
dc.creator Wall, Tamara L.
dc.creator Whitfield, John B.
dc.creator Zhao, Hongyu
dc.creator Neale, Benjamin M.
dc.creator Wade, Tracey D.
dc.creator Heath, Andrew C.
dc.creator Montgomery, Grant W.
dc.creator Martin, Nicholas G.
dc.creator Sullivan, Patrick F.
dc.creator Kaprio, Jaakko
dc.creator Breen, Gerome
dc.creator Gelernter, Joel
dc.creator Edenberg, Howard J.
dc.creator Bulik, Cynthia M.
dc.creator Agrawal, Arpana
dc.date 2021-01-05T18:49:25Z
dc.date WITHHELD_13_MONTHS
dc.date 2021-01-05T18:49:25Z
dc.date 2021-01
dc.date.accessioned 2022-05-19T13:14:50Z
dc.date.available 2022-05-19T13:14:50Z
dc.identifier Munn‐chernoff, Melissa A. ; Johnson, Emma C.; Chou, Yi‐ling ; Coleman, Jonathan R.I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hübel, Christopher ; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Héléna A. ; Bryois, Julien; Hinney, Anke; Leppä, Virpi M. ; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti‐rodríguez, Paola ; Hanscombe, Ken B.; Adan, Roger A.H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A.; Berrettini, Wade H.; Boehm, Ilka; Boni, Claudette; Boraska Perica, Vesna; Buehren, Katharina; Burghardt, Roland; Cassina, Matteo; Cichon, Sven; Clementi, Maurizio; Cone, Roger D.; Courtet, Philippe; Crow, Scott; Crowley, James J.; Danner, Unna N.; Davis, Oliver S.P.; Zwaan, Martina; Dedoussis, George; Degortes, Daniela; DeSocio, Janiece E.; Dick, Danielle M.; Dikeos, Dimitris; Dina, Christian; Dmitrzak‐weglarz, Monika ; Docampo, Elisa; Duncan, Laramie E.; Egberts, Karin; Ehrlich, Stefan; Escaramís, Geòrgia ; Esko, Tõnu ; Estivill, Xavier; Farmer, Anne; Favaro, Angela; Fernández‐aranda, Fernando ; Fichter, Manfred M.; Fischer, Krista; Föcker, Manuel ; Foretova, Lenka; Forstner, Andreas J.; Forzan, Monica; Franklin, Christopher S.; Gallinger, Steven; Giegling, Ina; Giuranna, Johanna; Gonidakis, Fragiskos; Gorwood, Philip; Gratacos Mayora, Monica; Guillaume, Sébastien ; Guo, Yiran; Hakonarson, Hakon; Hatzikotoulas, Konstantinos; Hauser, Joanna; Hebebrand, Johannes; Helder, Sietske G.; Herms, Stefan; Herpertz‐dahlmann, Beate ; Herzog, Wolfgang; Huckins, Laura M.; Hudson, James I.; Imgart, Hartmut; Inoko, Hidetoshi; Janout, Vladimir; Jiménez‐murcia, Susana ; Julià, Antonio ; Kalsi, Gursharan; Kaminská, Deborah ; Karhunen, Leila; Karwautz, Andreas; Kas, Martien J.H.; Kennedy, James L.; Keski‐rahkonen, Anna ; Kiezebrink, Kirsty; Kim, Youl‐ri ; Klump, Kelly L.; Knudsen, Gun Peggy S.; La Via, Maria C.; Le Hellard, Stephanie; Levitan, Robert D.; Li, Dong; Lilenfeld, Lisa; Lin, Bochao Danae; Lissowska, Jolanta; Luykx, Jurjen; Magistretti, Pierre J.; Maj, Mario; Mannik, Katrin; Marsal, Sara; Marshall, Christian R.; Mattingsdal, Morten; McDevitt, Sara; McGuffin, Peter; Metspalu, Andres; Meulenbelt, Ingrid; Micali, Nadia; Mitchell, Karen; Monteleone, Alessio Maria; Monteleone, Palmiero; Nacmias, Benedetta; Navratilova, Marie; Ntalla, Ioanna; O’Toole, Julie K.; Ophoff, Roel A.; Padyukov, Leonid; Palotie, Aarno; Pantel, Jacques; Papezova, Hana; Pinto, Dalila; Rabionet, Raquel; Raevuori, Anu; Ramoz, Nicolas; Reichborn‐kjennerud, Ted ; Ricca, Valdo; Ripatti, Samuli; Ritschel, Franziska; Roberts, Marion; Rotondo, Alessandro; Rujescu, Dan; Rybakowski, Filip; Santonastaso, Paolo; Scherag, André ; Scherer, Stephen W.; Schmidt, Ulrike; Schork, Nicholas J.; Schosser, Alexandra; Seitz, Jochen; Slachtova, Lenka; Slagboom, P. Eline; Slof‐op’T Landt, Margarita C.t. ; Slopien, Agnieszka; Sorbi, Sandro; Świątkowska, Beata ; Szatkiewicz, Jin P.; Tachmazidou, Ioanna; Tenconi, Elena; Tortorella, Alfonso; Tozzi, Federica; Treasure, Janet; Tsitsika, Artemis; Tyszkiewicz‐nwafor, Marta ; Tziouvas, Konstantinos; Elburg, Annemarie A.; Furth, Eric F.; Wagner, Gudrun; Walton, Esther; Widen, Elisabeth; Zeggini, Eleftheria; Zerwas, Stephanie; Zipfel, Stephan; Bergen, Andrew W.; Boden, Joseph M.; Brandt, Harry; Crawford, Steven; Halmi, Katherine A.; Horwood, L. John; Johnson, Craig; Kaplan, Allan S.; Kaye, Walter H.; Mitchell, James; Olsen, Catherine M.; Pearson, John F.; Pedersen, Nancy L.; Strober, Michael; Werge, Thomas; Whiteman, David C.; Woodside, D. Blake; Grove, Jakob; Henders, Anjali K.; Larsen, Janne T.; Parker, Richard; Petersen, Liselotte V.; Jordan, Jennifer; Kennedy, Martin A.; Birgegård, Andreas ; Lichtenstein, Paul; Norring, Claes; Landén, Mikael ; Mortensen, Preben Bo; Polimanti, Renato; McClintick, Jeanette N.; Adkins, Amy E.; Aliev, Fazil; Bacanu, Silviu‐alin ; Batzler, Anthony; Bertelsen, Sarah; Biernacka, Joanna M.; Bigdeli, Tim B.; Chen, Li‐shiun ; Clarke, Toni‐kim ; Degenhardt, Franziska; Docherty, Anna R.; Edwards, Alexis C.; Foo, Jerome C.; Fox, Louis; Frank, Josef; Hack, Laura M.; Hartmann, Annette M.; Hartz, Sarah M.; Heilmann‐heimbach, Stefanie ; Hodgkinson, Colin; Hoffmann, Per; Hottenga, Jouke‐jan ; Konte, Bettina; Lahti, Jari; Lahti‐pulkkinen, Marius ; Lai, Dongbing; Ligthart, Lannie; Loukola, Anu; Maher, Brion S.; Mbarek, Hamdi; McIntosh, Andrew M.; McQueen, Matthew B.; Meyers, Jacquelyn L.; Milaneschi, Yuri; Palviainen, Teemu; Peterson, Roseann E.; Ryu, Euijung; Saccone, Nancy L.; Salvatore, Jessica E.; Sanchez‐roige, Sandra ; Schwandt, Melanie; Sherva, Richard; Streit, Fabian; Strohmaier, Jana; Thomas, Nathaniel; Wang, Jen‐chyong ; Webb, Bradley T.; Wedow, Robbee; Wetherill, Leah; Wills, Amanda G.; Zhou, Hang; Boardman, Jason D.; Chen, Danfeng; Choi, Doo‐sup ; Copeland, William E.; Culverhouse, Robert C.; Dahmen, Norbert; Degenhardt, Louisa; Domingue, Benjamin W.; Frye, Mark A.; Gäebel, Wolfgang ; Hayward, Caroline; Ising, Marcus; Keyes, Margaret; Kiefer, Falk; Koller, Gabriele; Kramer, John; Kuperman, Samuel; Lucae, Susanne; Lynskey, Michael T.; Maier, Wolfgang; Mann, Karl; Männistö, Satu ; Müller‐myhsok, Bertram ; Murray, Alison D.; Nurnberger, John I.; Preuss, Ulrich; Räikkönen, Katri ; Reynolds, Maureen D.; Ridinger, Monika; Scherbaum, Norbert; Schuckit, Marc A.; Soyka, Michael; Treutlein, Jens; Witt, Stephanie H.; Wodarz, Norbert; Zill, Peter; Adkins, Daniel E.; Boomsma, Dorret I.; Bierut, Laura J.; Brown, Sandra A.; Bucholz, Kathleen K.; Costello, E. Jane; Wit, Harriet; Diazgranados, Nancy; Eriksson, Johan G.; Farrer, Lindsay A.; Foroud, Tatiana M.; Gillespie, Nathan A.; Goate, Alison M.; Goldman, David; Grucza, Richard A.; Hancock, Dana B.; Harris, Kathleen Mullan; Hesselbrock, Victor; Hewitt, John K.; Hopfer, Christian J.; Iacono, William G.; Johnson, Eric O.; Karpyak, Victor M.; Kendler, Kenneth S.; Kranzler, Henry R.; Krauter, Kenneth; Lind, Penelope A.; McGue, Matt; MacKillop, James; Madden, Pamela A.F.; Maes, Hermine H.; Magnusson, Patrik K.E.; Nelson, Elliot C.; Nöthen, Markus M. ; Palmer, Abraham A.; Penninx, Brenda W.J.H.; Porjesz, Bernice; Rice, John P.; Rietschel, Marcella; Riley, Brien P.; Rose, Richard J.; Shen, Pei‐hong ; Silberg, Judy; Stallings, Michael C.; Tarter, Ralph E.; Vanyukov, Michael M.; Vrieze, Scott; Wall, Tamara L.; Whitfield, John B.; Zhao, Hongyu; Neale, Benjamin M.; Wade, Tracey D.; Heath, Andrew C.; Montgomery, Grant W.; Martin, Nicholas G.; Sullivan, Patrick F.; Kaprio, Jaakko; Breen, Gerome; Gelernter, Joel; Edenberg, Howard J.; Bulik, Cynthia M.; Agrawal, Arpana (2021). "Shared genetic risk between eating disorder- and substance- use- related phenotypes: Evidence from genome- wide association studies." Addiction Biology 26(1): n/a-n/a.
dc.identifier 1355-6215
dc.identifier 1369-1600
dc.identifier https://hdl.handle.net/2027.42/163964
dc.identifier 10.1111/adb.12880
dc.identifier Addiction Biology
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dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/115730
dc.description Eating disorders and substance use disorders frequently co- occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin- based = 0.23- 0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome- wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance- use- related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism- based genetic correlations between eating disorder- and substance- use- related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = - 0.19 to - 0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co- varying for major depressive disorder loci. The patterns of association between eating disorder- and substance- use- related phenotypes highlights the potentially complex and substance- specific relationships among these behaviors.Eating disorders and substance use disorders frequently co- occur. Using genome- wide association studies, we found differential patterns of genetic correlations between specific eating disorder- and substance- use- related phenotypes. These patterns of association highlight the potentially complex and substance- specific associations among eating disorder- and substance- use- related behaviors.
dc.description Peer Reviewed
dc.description http://deepblue.lib.umich.edu/bitstream/2027.42/163964/1/adb12880.pdf
dc.description http://deepblue.lib.umich.edu/bitstream/2027.42/163964/2/adb12880_am.pdf
dc.format application/pdf
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dc.publisher The National Center on Addiction and Substance Abuse at Columbia University
dc.publisher Wiley Periodicals, Inc.
dc.rights IndexNoFollow
dc.subject eating disorders
dc.subject genetic correlation
dc.subject substance use
dc.subject Neurology and Neurosciences
dc.subject Health Sciences
dc.title Shared genetic risk between eating disorder- and substance- use- related phenotypes: Evidence from genome- wide association studies
dc.type Article


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