| dc.contributor |
Department of Internal Medicine (Division of Cardiology) University of Michigan Medical Center, Ann Arbor, Mich., USA |
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| dc.contributor |
Department of Radiology, University of Michigan Medical Center, Ann Arbor, Mich., USA |
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| dc.contributor |
Department of Radiology, University of Michigan Medical Center, Ann Arbor, Mich., USA |
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| dc.contributor |
Department of Radiology, University of Michigan Medical Center, Ann Arbor, Mich., USA |
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| dc.contributor |
Department of Internal Medicine (Division of Cardiology) University of Michigan Medical Center, Ann Arbor, Mich., USA; Department of Medicine (Cardiology Section), Tulane University Medical Center, New Orleans, La., USA. |
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| dc.creator |
Marcovitz, Pamela M. |
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| dc.creator |
Aisen, Alex M. |
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| dc.creator |
Fencil, Laura E. |
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| dc.creator |
Swanson, Scott D. |
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| dc.creator |
Buda, Andrew J. |
|
| dc.date |
2006-04-10T15:01:47Z |
|
| dc.date |
2006-04-10T15:01:47Z |
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| dc.date |
1992-11 |
|
| dc.date.accessioned |
2022-05-19T13:30:08Z |
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| dc.date.available |
2022-05-19T13:30:08Z |
|
| dc.identifier |
Marcovitz, Pamela M., Aisen, Alex M., Fencil, Laura E., Swanson, Scott D., Buda, Andrew J. (1992/11)."Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy." American Heart Journal 124(5): 1205-1212. <http://hdl.handle.net/2027.42/29773> |
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| dc.identifier |
http://www.sciencedirect.com/science/article/B6W9H-4BKY6VY-D/2/bcd89ebd76728fa8ce0eae4144406a71 |
|
| dc.identifier |
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1442487&dopt=citation |
|
| dc.identifier |
http://hdl.handle.net/2027.42/29773 |
|
| dc.identifier |
1442487 |
|
| dc.identifier |
http://dx.doi.org/10.1016/0002-8703(92)90401-G |
|
| dc.identifier |
American Heart Journal |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/117327 |
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| dc.description |
The metabolic effects of adenosine on regionally ischemic myocardium were investigated in an open-chest rabbit model by means of phosphorus 31 nuclear magnetic resonance (NMR) spectroscopy. Sixteen anesthetized New Zealand white rabbits were subjected to thoracotomy; a reversible snare occluder was placed around a large branch of the left circumflex coronary artery, and an NMR surface coil was positioned adjacent to the myocardium perfused by this vessel. The animals were placed in a 2.0 T CSI spectrometer (GE Medical Systems, Fremont, Calif.), and baseline spectra were acquired. Eight animals were treated with intravenous adenosine (25 mg/kg), and eight rabbits served as control subjects. All animals were subjected to a 10-minute period of ischemia followed by a period of reperfusion. NMR spectra were acquired during both intervals. During the occlusion period, expected increases in inorganic phosphate levels and decreases in phosphocreatine levels were observed in both groups; however, inorganic phosphate increased less in adenosine-treated animals (adenosine: 33 +/- 2.8% total spectral area during occlusion vs control: 41+/-3.1%) and phosphocreatine diminished less with adenosine (adenosine: 26+/-3% vs control: 13+/-1.2%; p<0.002). No significant differences were seen in [beta]-adenosine triphosphate levels. In both groups the metabolite levels during reperfusion recovered to near baseline values, although phosphocreatine remained slightly higher in the treated group during early reperfusion. An apparent cardioprotective effect of adenosine on relative phosphocreatine and inorganic phosphate levels can be observed in intact rabbits by means of phosphorus 31 NMR spectroscopy. |
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| dc.description |
Peer Reviewed |
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| dc.description |
http://deepblue.lib.umich.edu/bitstream/2027.42/29773/1/0000112.pdf |
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| dc.format |
958259 bytes |
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| dc.format |
3118 bytes |
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| dc.format |
application/pdf |
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| dc.format |
text/plain |
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| dc.format |
application/pdf |
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| dc.language |
en_US |
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| dc.publisher |
Elsevier |
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| dc.rights |
IndexNoFollow |
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| dc.subject |
Internal Medicine and Specialties |
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| dc.subject |
Health Sciences |
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| dc.title |
Metabolic effects of adenosine on regional myocardial ischemia by phosphorus 31 nuclear magnetic resonance spectroscopy |
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| dc.type |
Article |
|