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Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation

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dc.contributor Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI, USA
dc.contributor Departments of Molecular and Experimental Medicine and of Vascular Biology, The Scripps Research Institute, La Jolla, CA, USA;
dc.contributor The Howard Hughes Medical Institute,
dc.creator Heeb, Mary J.
dc.creator Rehemtulla, Al
dc.creator Moussalli, Micheline
dc.creator Kojima, Yumi
dc.creator Kaufman, Randal J.
dc.date 2010-04-01T15:52:30Z
dc.date 2010-04-01T15:52:30Z
dc.date 1999-02-05
dc.date.accessioned 2022-05-19T13:30:38Z
dc.date.available 2022-05-19T13:30:38Z
dc.identifier Heeb, Mary J.; Rehemtulla, Al; Moussalli, Micheline; Kojima, Yumi; Kaufman, Randal J. (1999). "Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation." European Journal of Biochemistry 260(1): 64-75. <http://hdl.handle.net/2027.42/66371>
dc.identifier 0014-2956
dc.identifier 1432-1033
dc.identifier http://hdl.handle.net/2027.42/66371
dc.identifier http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10091585&dopt=citation
dc.identifier 10091585
dc.identifier 10.1046/j.1432-1327.1999.00137.x
dc.identifier European Journal of Biochemistry
dc.identifier Rosing, J., Tans, G., Govers-Riemslag, J.W.P., Zwaal, R.F.A., Hemker, H.C. ( 1980 ) The role of phospholipids and factor Va in the prothrombinase complex. J. Biol. Chem. 255, 274 283.
dc.identifier Mann, K.G., Nesheim, M.E., Hibbard, L.S., Tracy, P.B. ( 1981 ) The role of factor V in the assembly of the prothrombinase complex. In Annals of the New York Academy of Sciences ( Walz, D.A. & McCoy, L.E., eds.), pp. 378 388. New York Academy of Sciences, New York.
dc.identifier Tracy, P.B. & Mann, K.G. ( 1983 ) Prothrombinase complex assembly on the platelet surface is mediated through the 74,000-dalton component of factor Va. Proc. Natl Acad. Sci. USA 80, 2380 2384.
dc.identifier Krishnaswamy, S., Church, W.R., Nesheim, M.E., Mann, K.G. ( 1988 ) Activation of human prothrombin by human prothrombinase: influence of factor Va on the reaction mechanism. J. Biol. Chem. 262, 3291 3299.
dc.identifier Kisiel, W., Canfield, W.M., Ericsson, L.H., Davie, E.W. ( 1977 ) Anticoagulant properties of bovine plasma protein C following activation by thrombin. Biochemistry 16, 5824 5831.
dc.identifier Odegaard, B. & Mann, K. ( 1987 ) Proteolysis of factor Va by factor Xa and activated protein C. J. Biol. Chem. 262, 11233 11238.
dc.identifier Suzuki, K., Stenflo, J.A., DahlbÄck, B., Teodorsson, B. ( 1983 ) Inactivation of human coagulation factor V by activated protein C. J. Biol. Chem. 258, 1914 1920.
dc.identifier Griffin, J.H., Evatt, B., Zimmerman, T.S., Kleiss, A.J., Wideman, C. ( 1981 ) Deficiency of protein C in congenital thrombotic disease. J. Clin. Invest. 68, 1370 1373.
dc.identifier Branson, H.E., Katz, J., Marble, R., Griffin, J.H. ( 1983 ) Inherited protein C deficiency and a coumarin-responsive chronic relapsing purpura fulminans syndrome in a neonate. Lancet 2, 1165 1168.
dc.identifier Mannucci, P.M. & Vigano, S. ( 1982 ) Deficiencies of protein C, an inhibitor of blood coagulation. Lancet 2, 463 466.
dc.identifier Bertina, R.M., Broekmans, A.W., van der Linden, I.K., Mertens, K. ( 1982 ) Protein C deficiency in a Dutch family with thrombotic disease. Thromb. Haemost. 48, 1 5.
dc.identifier DahlbÄck, B., Carlsson, M., Svensson, P.J. ( 1993 ) Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc. Natl Acad. Sci. USA 90, 1004 1008.
dc.identifier Svensson, P.J. & DahlbÄck, B. ( 1994 ) Resistance to activated protein C as a basis for venous thrombosis. N. Engl. J. Med. 330, 517 522.
dc.identifier Griffin, J.H., Evatt, B., Wideman, C., FernÁndez, J.A. ( 1993 ) Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 82, 1989 1993.
dc.identifier Koster, T., Rosendaal, F.R., de Ronde, H., Briet, E., Vandenbroucke, J.P., Bertina, R. ( 1993 ) Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study. Lancet 342, 1503 1506.
dc.identifier Sun, X., Evatt, B., Griffin, J.H. ( 1994 ) Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia. Blood 83, 3120 3125.
dc.identifier Bertina, R.M., Koeleman, B.P.C., Koster, T., Rosendaal, F.R., Dirven, R.J., de Ronde, H., van der Velden, P.A., Reitsma, P.H. ( 1994 ) Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369, 64 67.
dc.identifier Greengard, J.S., Sun, X., Xu, X., FernÁndez, J.A., Griffin, J.H., Evatt, B. ( 1994 ) Activated protein C resistance caused by Arg506Gln mutation in factor Va. Lancet 343, 1361 1362.
dc.identifier Voorberg, J., Roelse, J., Koopman, R., BÜller, H., Berends, F., ten Cate, J.W., Mertens, K., van Mourik, J.A. ( 1994 ) Association of idiopathic venous thromboembolism with single point-mutation at Arg 506 of factor V. Lancet 343, 1535 1536.
dc.identifier Koeleman, B.P.C., Reitsma, P.H., Allaart, C.F., Bertina, R.M. ( 1994 ) Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 84, 1031 1035.
dc.identifier ZÖller, B., He, X., DahlbÄck, B. ( 1995 ) Homozygous APC-resistance combined with inherited type I protein S deficiency in a young boy with severe thrombotic disease. Thromb. Haemost. 73, 743 745.
dc.identifier Gandrille, S., Greengard, J.S., Alhenc-Gelas, M., Juhan-Vague, I., Abgrall, J.F., Jude, B., Griffin, J.H., Aiach, M. & French Network on the behalf of INSERM ( 1995 ) Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. Blood 86, 219 224.
dc.identifier Brenner, B., Zivelin, A., Lanir, N., Greengard, J.S., Griffin, J.H., Seligsohn, U. ( 1996 ) Venous thromboembolism associated with double heterozygosity for R506Q: mutation of factor V and for T298M: mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis. Blood 88, 877 880.
dc.identifier Kalafatis, M. & Mann, K.G. ( 1993 ) Role of the membrane in the inactivation of factor Va by activated protein C. J. Biol. Chem. 268, 27246 27257.
dc.identifier Kalafatis, M., Rand, M.D., Mann, K.G. ( 1994 ) The mechanism of inactivation of human factor V and human factor Va by activated protein C. J. Biol. Chem. 269, 31869 31880.
dc.identifier Rosing, J., Hoekema, L., Nicolaes, G.A.F., Thomassen, M.C.L.G.D., Hemker, H.C., Varadi, K., Schwarz, H.P., Tans, G. ( 1995 ) Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor Va R506Q by activated protein C. J. Biol. Chem. 270, 27852 27858.
dc.identifier Kalafatis, M., Bertina, R.M., Rand, M.D., Mann, K.G. ( 1995 ) Characterization of the molecular defect in factor V R506Q. J. Biol. Chem. 270, 4053 4057.
dc.identifier Heeb, M.J., Kojima, Y., Greengard, J., Griffin, J.H. ( 1995 ) Activated protein C resistance: molecular mechanisms based on studies using purified Gln 506 -factor V. Blood 85, 3405 3411.
dc.identifier Nicolaes, G.A.F., Tans, G., Thomassen, M.C.L.G.D., Hemker, H.C., Pabringer, I., Varadi, K., Schwarz, H.P., Rosing, J. ( 1995 ) Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor Va R506Q by activated protein C. J. Biol. Chem. 270, 21158 21166.
dc.identifier Pittman, D.D. & Kaufman, R.J. ( 1993 ) Site-directed mutagenesis and expression in mammalian cells to evaluate structure–function relationships in coagulation factors V and VIII. Methods Enzymol. 222, 236 260.
dc.identifier Marquette, K.A., Pittman, D.D., Kaufman, R.J. ( 1995 ) The factor V B-domain provides two functions to facilitate thrombin cleavage and release of the light chain. Blood 86, 3026 3034.
dc.identifier Keller, F.G., Ortel, T.L., Quinn-Allen, M.A., Kane, W.H. ( 1995 ) Thrombin-catalyzed activation of recombinant human factor V. Biochemistry 34, 4118 4124.
dc.identifier Egan, J.O., Kalafatis, M., Mann, K.G. ( 1997 ) The effect of Arg 306 → Ala and Arg 506 → Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S. Protein Sci. 6, 2016 2027.
dc.identifier Yan, T.L., Cui, J., Rehemtulla, A., Yang, A., Moussalli, M., Kaufman, R.J., Ginsburg, D. ( 1998 ) The structure and function of murine factor V and its inactivation by protein C. Blood 91, 4593 4599.
dc.identifier Thorelli, E., Kaufman, R.J., Dahlback, B. ( 1997 ) Cleavage requirements for activation of factor V by factor Xa. Eur. J. Biochem. 247, 12 20.
dc.identifier Heeb, M.J., Rehemtulla, A., Moussalli, M., Kojima, Y., Griffin, J.H., Kaufman, R.J. ( 1996 ) Importance of individual activated protein C cleavage sites in the heavy chain of factor V and Va. Blood 88, 440a.
dc.identifier Heeb, M.J., Rehemtulla, A., Moussalli, M., Kojima, Y., Griffin, J.H. ( 1997 ). Arginine-306 is the most important activated protein C cleavage site for efficient inactivaiton of factor Va, but not of factor V. Thromb Haemostas ( Suppl. ) 598 (Abstract).
dc.identifier Gruber, A., Griffin, J.H., Harker, L., Hanson, S.R. ( 1989 ) Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model. Blood 73, 639 642.
dc.identifier Tans, G., Rosing, J., Thomassen, M.C., Heeb, M.J., Zwaal, R.F.A., Griffin, J.H. ( 1991 ) Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood 77, 2641 2648.
dc.identifier DiScipio, R.G., Hermodson, M.A., Yates, S.G., Davie, E.W. ( 1977 ) A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry 16, 698 706.
dc.identifier Heeb, M.J., Mesters, R.M., Tans, G., Rosing, J., Griffin, J.H. ( 1993 ) Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C. J. Biol. Chem. 268, 2872 2877.
dc.identifier Kaufman, R.J., Davies, M.V., Wasley, L.C., Michnick, D. ( 1991 ) Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucleic Acids Res. 19, 4485 4490.
dc.identifier Nesheim, M.E., Eid, S., Mann, K.G. ( 1981 ) Assembly of the prothrombinase complex in the absence of prothrombin. J. Biol. Chem. 256, 9874 9882.
dc.identifier Mesters, R.M., Houghten, R.A., Griffin, J.H. ( 1991 ) Identification of a sequence of human activated protein C (residues 390–404) essential for its anticoagulant activity. J. Biol. Chem. 266, 24514 24519.
dc.identifier Pittman, D.D., Marquette, K.A., Kaufman, R.J. ( 1994 ) Role of the B-domain for factor VIII and factor V expression and function. Blood 84, 4214 4225.
dc.identifier Monkovic, D.D. & Tracy, P.B. ( 1990 ) Activation of human factor V by factor Xa and thrombin. Biochemistry 29, 1118 1128.
dc.identifier Mann, K.G., Hockin, M.F., Begin, K.J., Kalafatis, M. ( 1997 ) Activated protein C cleavage of factor Va leads to dissociation of the A2 domain. J. Biol. Chem. 272, 20678 20683.
dc.identifier FernÁndez, J.A., Hackeng, T.M., Kojima, K., Griffin, J.H. ( 1997 ) The carbohydrate moiety of factor V modulates inactivation by activated protein C. Blood 89, 4348 4354.
dc.identifier Rosing, J., Bakker, H., Thomassen, M.C.L.G.D., Thomassen, L., Hemker, H., Tans, G. ( 1993 ) Characterization of two forms of human factor Va with different cofactor activities. J. Biol. Chem. 268, 21130 21136.
dc.identifier Ortel, T.L., Quinn-Allen, M.A., Keller, F.G., Peterson, J.A., Larocca, D., Kane, W.H. ( 1994 ) Localization of functionally important epitopes within the second C-type domain of coagulation factor V using recombinant chimeras. J. Biol. Chem. 269, 15898 15905.
dc.identifier Kalafatis, M., Rand, M.D., Jenny, R.J., Ehrlich, Y.H., Mann, K.G. ( 1993 ) Phosphorylation of factor Va and factor VIIIa by activated platelets. Blood 81, 704 719.
dc.identifier Pittman, D.D., Tomkinson, K.N., Michnick, D., Selighsohn, U., Kaufman, R.J. ( 1994 ) Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. Biochemistry 33, 6952 6959.
dc.identifier Chan, W.P., Lee, C.K., Kwong, Y.L., Lam, C.K., Liang, R. ( 1998 ) A novel mutation of Arg306 of factor V gene in Hong Kong Chinese. Blood 91, 1135 1139.
dc.identifier Williamson, D., Brown, K., Luddington, R., Baglin, C., Baglin, T. ( 1998 ) Factor V Cambridge: a new mutation (Arg 306 →Thr) associated with resistance to activated protein C. Blood 91, 1140 1144.
dc.identifier Wei, C.-J., Quinn-Allen, M.-A., Kane, W.H. ( 1995 ) Cleavage at arginine 306 is not required for inactivation of factor V by activated protein C (APC). Blood 86, 615a. (Abstract).
dc.identifier Gale, A.J., Sun, X., Heeb, M.J., Griffin, J.H. ( 1997 ) Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala-activated protein C mediated by factor Va. Protein Sci. 6, 132 140.
dc.identifier Heeb, M.J., Kojima, Y., Hackeng, T.M., Griffin, J.H. ( 1996 ) Binding sites for blood coagulation factor Xa and protein S involving residues 493–506 in factor Va. Protein Sci. 5, 1883 1889.
dc.identifier Kojima, Y., Heeb, M.J., Gale, A., Hackeng, T.M., Griffin, J.H. ( 1998 ) Binding sites for coagulation factor Xa involving residues 311–335 in factor Va. J. Biol. Chem. 273, 14900 14905.
dc.identifier Pemberton, S., Lindley, P., Zaitsev, V., Card, G., Tuddenham, E.G.D., Kemball-Cook, G. ( 1997 ) A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. Blood 89, 2413 2421.
dc.identifier Heeb, M.J., Kojima, Y., Hackeng, T.M., Griffin, J.H. ( 1994 ) Functional studies of factor Va residues 493–506 related to activated protein C resistance. Blood 84, 391a. (Abstract).
dc.identifier Mesters, R.M., Heeb, M.J., Griffin, J.H. ( 1993 ) Interactions and inhibition of blood coagulation factor Va involving residues 311–325 of activated protein C. Protein Sci. 2, 1482 1489.
dc.identifier Kojima, Y., Heeb, M.J., Hackeng, T.M., Gale, A., Griffin, J.H. ( 1997 ) Binding sites for coagulation factor Xa and activated protein C involving residues 311–335 in factor Va. Thromb. Haemost. ( Suppl. ) June, 423 424 (Abstract).
dc.identifier Nesheim, M.E., Canfield, W.M., Kisiel, W., Mann, K.G. ( 1982 ) Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C. J. Biol. Chem. 257, 1443 1447.
dc.identifier Ye, J. & Esmon, C.T. ( 1995 ) Factor Xa-factor Va complex assembles in two dimensions with unexpectedly high affinity: an experimental and theoretical approach. Biochemistry 34, 6448 6453.
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/117376
dc.description Peer Reviewed
dc.description http://deepblue.lib.umich.edu/bitstream/2027.42/66371/1/j.1432-1327.1999.00137.x.pdf
dc.format 914251 bytes
dc.format 3110 bytes
dc.format application/pdf
dc.format text/plain
dc.format application/pdf
dc.publisher Blackwell Science Ltd
dc.rights FEBS, 1999
dc.rights IndexNoFollow
dc.subject Activated Protein C
dc.subject Activated Protein C Resistance
dc.subject Blood Coagulation
dc.subject Factor Va
dc.subject Factor Xa
dc.subject Biological Chemistry
dc.subject Science
dc.title Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation
dc.type Article


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