Sangam: A Confluence of Knowledge Streams

NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells

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dc.creator Stafford, Benjamin K.
dc.creator Manookin, Michael B.
dc.creator Singer, Joshua H.
dc.creator Demb, Jonathan B.
dc.date 2014-12-09T16:53:34Z
dc.date WITHHELD_12_MONTHS
dc.date 2014-12-09T16:53:34Z
dc.date 2014-11-15
dc.date.accessioned 2022-05-19T13:30:39Z
dc.date.available 2022-05-19T13:30:39Z
dc.identifier Stafford, Benjamin K.; Manookin, Michael B.; Singer, Joshua H.; Demb, Jonathan B. (2014). "NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells." The Journal of Physiology 592(22): 4877-4889.
dc.identifier 0022-3751
dc.identifier 1469-7793
dc.identifier http://hdl.handle.net/2027.42/109576
dc.identifier 10.1113/jphysiol.2014.276543
dc.identifier The Journal of Physiology
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dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/117378
dc.description Postsynaptic AMPA‐ and NMDA‐type glutamate receptors (AMPARs, NMDARs) are commonly expressed at the same synapses. AMPARs are thought to mediate the majority of fast excitatory neurotransmission whereas NMDARs, with their relatively slower kinetics and higher Ca 2+ permeability, are thought to mediate synaptic plasticity, especially in neural circuits devoted to learning and memory. In sensory neurons, however, the roles of AMPARs and NMDARs are less well understood. Here, we tested in the in vitro guinea pig retina whether AMPARs and NMDARs differentially support temporal contrast encoding by two ganglion cell types. In both OFF Alpha and Delta ganglion cells, contrast stimulation evoked an NMDAR‐mediated response with a characteristic J‐shaped I–V relationship. In OFF Delta cells, AMPAR‐ and NMDAR‐mediated responses could be modulated at low frequencies but were suppressed during 10 Hz stimulation, when responses were instead shaped by synaptic inhibition. With inhibition blocked, both AMPAR‐ and NMDAR‐mediated responses could be modulated at 10 Hz, indicating that NMDAR kinetics do not limit temporal encoding. In OFF Alpha cells, NMDAR‐mediated responses followed stimuli at frequencies up to ∼18 Hz. In both cell types, NMDAR‐mediated responses to contrast modulation at 9–18 Hz showed delays of <10 ms relative to AMPAR‐mediated responses. Thus, NMDARs combine with AMPARs to encode rapidly modulated glutamate release, and NMDAR kinetics do not limit temporal coding by OFF Alpha and Delta ganglion cells substantially. Furthermore, glutamatergic transmission is differentially regulated across bipolar cell pathways: in some, release is suppressed at high temporal frequencies by presynaptic inhibition.
dc.description Peer Reviewed
dc.description http://deepblue.lib.umich.edu/bitstream/2027.42/109576/1/tjp6355.pdf
dc.format application/pdf
dc.publisher Wiley Periodicals, Inc.
dc.rights IndexNoFollow
dc.subject Physiology
dc.subject Health Sciences
dc.title NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells
dc.type Article


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