| dc.contributor |
University of Aberdeen.Applied Medicine |
|
| dc.contributor |
University of Aberdeen.Institute of Medical Sciences |
|
| dc.contributor |
University of Aberdeen.Chemistry |
|
| dc.contributor |
University of Aberdeen.Medical Sciences |
|
| dc.contributor |
University of Aberdeen.Chemistry (Research Theme) |
|
| dc.contributor |
University of Aberdeen.Clinical Medicine |
|
| dc.creator |
Al-Hilaly, Youssra K. |
|
| dc.creator |
Pollack, Saskia J. |
|
| dc.creator |
Rickard, Janet E. |
|
| dc.creator |
Simpson, Michael |
|
| dc.creator |
Raulin, Ana-C |
|
| dc.creator |
Baddeley, Thomas |
|
| dc.creator |
Schellenberger, Pascale |
|
| dc.creator |
Storey, John M. D. |
|
| dc.creator |
Harrington, Charles R. |
|
| dc.creator |
Wischik, Claude M. |
|
| dc.creator |
Serpell, Louise C. |
|
| dc.date |
2018-10-12T14:00:07Z |
|
| dc.date |
2018-10-12T14:00:07Z |
|
| dc.date |
2018-10-19 |
|
| dc.date.accessioned |
2022-05-24T06:10:06Z |
|
| dc.date.available |
2022-05-24T06:10:06Z |
|
| dc.identifier |
Al-Hilaly , Y K , Pollack , S J , Rickard , J E , Simpson , M , Raulin , A-C , Baddeley , T , Schellenberger , P , Storey , J M D , Harrington , C R , Wischik , C M & Serpell , L C 2018 , ' Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT) ' , Journal of Molecular Biology , vol. 430 , no. 21 , pp. 4119-4131 . https://doi.org/10.1016/j.jmb.2018.08.010 |
|
| dc.identifier |
0022-2836 |
|
| dc.identifier |
PURE: 131367224 |
|
| dc.identifier |
PURE UUID: 7347ac83-315c-4c76-896c-529fcfeb7a17 |
|
| dc.identifier |
PubMed: 30121297 |
|
| dc.identifier |
Scopus: 85053053674 |
|
| dc.identifier |
WOS: 000448493400017 |
|
| dc.identifier |
ORCID: /0000-0002-5261-5467/work/73579165 |
|
| dc.identifier |
http://hdl.handle.net/2164/11249 |
|
| dc.identifier |
https://doi.org/10.1016/j.jmb.2018.08.010 |
|
| dc.identifier |
430 |
|
| dc.identifier |
21 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/117882 |
|
| dc.description |
TEM work was performed at the School of Life Sciences TEM Imaging Centre at the University of Sussex, which is supported by the Wellcome Trust and RM Phillips. SP and AR are supported by a Sussex Neuroscience doctoral training centre. LCS is supported by Alzheimer's Society and Alzheimer's Research UK Southcoast Network. YA, JR, TB and MS are supported by TauRx Therapeutics Ltd. and CH, JS and CW serve as officers in TauRx Therapeutics Ltd. |
|
| dc.description |
Peer reviewed |
|
| dc.description |
Publisher PDF |
|
| dc.format |
13 |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.relation |
Journal of Molecular Biology |
|
| dc.rights |
Under a Creative Commons license https://creativecommons.org/licenses/by/4.0/ |
|
| dc.subject |
Tau |
|
| dc.subject |
Methylthioninium |
|
| dc.subject |
Hydromethylthionine |
|
| dc.subject |
Neurofibrillary tangles |
|
| dc.subject |
Circular dichroism |
|
| dc.subject |
Electron microscopy |
|
| dc.subject |
RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
|
| dc.subject |
QD Chemistry |
|
| dc.subject |
Alzheimers Research UK |
|
| dc.subject |
RC0321 |
|
| dc.subject |
QD |
|
| dc.title |
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT) |
|
| dc.type |
Journal article |
|