Sangam: A Confluence of Knowledge Streams

Cytochrome P450 1B1 (CYP1B1) is over-expressed in human colon adeno-carcinomas relative to normal colon: Implications for drug development.

Show simple item record

dc.creator Gibson, Paul
dc.creator Gill, Jason H.
dc.creator Khan, Parveen A.
dc.creator Seargent, Jill M.
dc.creator Martin, Sandie W.
dc.creator Batman, Philip A.
dc.creator Griffith, John
dc.creator Bradley, C.
dc.creator Double, John A.
dc.creator Bibby, Michael C.
dc.creator Loadman, Paul M.
dc.date 2009-12-08T12:40:20Z
dc.date 2009-12-08T12:40:20Z
dc.date 2003
dc.identifier Gibson, P., Gill, J.H., Khan, P.A. et all (2003). Cytochrome P450 1B1 (CYP1B1) is over-expressed in human colon adeno-carcinomas relative to normal colon: Implications for drug development. Molecular Cancer Therapeutics, Vol. 2, No. 6, pp. 527-534.
dc.identifier http://hdl.handle.net/10454/4043
dc.description no
dc.description The cytochrome P450 family of enzymes is involved in the Phase I metabolism of a wide variety of compounds. Although generally involved with detoxification, overexpression of one family member, cytochrome P450 1B1 (CYP1B1), has been associated with human epithelial tumors. As such, CYP1B1 was hypothesized to be a novel target for the development of anticancer therapies. We investigated expression of CYP1B1 protein in 61 human colorectal adenocarcinomas and compared this to that observed in 14 histologically normal human large bowel samples removed from patients undergoing surgery for large bowel tumors. Although we confirmed that CYP1B1 was expressed at high levels in human colorectal tumor epithelia, we also found that CYP1B1 was not absent from normal colonic epithelia but was expressed at low levels. The expression of CYP1B1 in colon tumors does not correlate with tumor stage or degree of lymph node invasion in this study. Furthermore, in addition to expression in colon epithelia, CYP1B1 is also observed in blood vessels within the colon. As with the epithelia, levels of CYP1B1 were higher in tumor vasculature than that of the normal colon. Although these observations greatly support the development of CYP1B1 targeted anticancer therapies, they also indicate the caution that should be observed when developing such drugs.
dc.language en
dc.publisher American Association for Cancer Research
dc.relation http://mct.aacrjournals.org/content/2/6/527.abstract
dc.subject Cytochrome P450 1B1 (CYP1B1)
dc.subject Human colon adenocarcinomas
dc.subject Drug development
dc.title Cytochrome P450 1B1 (CYP1B1) is over-expressed in human colon adeno-carcinomas relative to normal colon: Implications for drug development.
dc.type Article
dc.type published version paper


Files in this item

Files Size Format View

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse