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The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis

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dc.creator Schallreuter, Karin U.
dc.creator Chavan, Bhavan
dc.creator Elwary, Souna M.A.
dc.date 2009-12-14T08:54:09Z
dc.date 2009-12-14T08:54:09Z
dc.date 2006
dc.identifier Schallreuter, K.U., Chavan, B. and Elwary, S.M. (2006). The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis. Journal of Investigative Dermatology. Vol. 126, No. , pp. 1879-1884.
dc.identifier http://hdl.handle.net/10454/4078
dc.description No
dc.description The human epidermis holds the full machinery for cholinergic signal transduction. However, the presence of the vesicular transporter (vesicular acetylcholine (ACh) transporter (VAChT)) for both choline and ACh has never been shown in this compartment. The results of this study confirm the presence of VAChT in cutaneous nerves and in both epidermal melanocytes and keratinocytes as well as in their nuclei using immunofluorescence labelling in situ and in vitro, Western blot analysis of cellular and nuclear extracts and reverse transcription-PCR. These results underline that ACh/choline transport in the non-neuronal epidermis is no different from the neuronal pathway. However, the function of VAChT in the nucleus remains to be shown.
dc.language en
dc.relation http://dx.doi.org/10.1038/sj.jid.5700268
dc.subject Human Epidermis
dc.subject Melanocytes
dc.subject Keratinocytes
dc.subject VAChT
dc.subject Vesicular Acetylcholine Transporter
dc.title The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis
dc.type Article
dc.type No full-text available in the repository


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