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Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

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dc.creator Lv, J
dc.creator Cao, J
dc.creator Cai, Y
dc.creator Zhou, Y
dc.creator Long, Q
dc.creator Yao, W
dc.creator Xu, S
dc.date 2011-07-21T14:37:42Z
dc.date 2011-07-21T14:37:42Z
dc.date 2011
dc.date.accessioned 2022-05-25T13:49:13Z
dc.date.available 2022-05-25T13:49:13Z
dc.identifier Journal of Applied Mathematics, Article 190371, Mar 2011
dc.identifier 1110-757X
dc.identifier http://bura.brunel.ac.uk/handle/2438/5609
dc.identifier http://dx.doi.org/10.1155/2011/190371
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/168499
dc.description This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi Publishing
dc.description To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.
dc.publisher Hindawi Publishing Corporation
dc.title Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy
dc.type Article


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