Exponential wash-off models are the most widely used method to predict sediment wash-off from urban surfaces. In spite of many studies, there is still a lack of knowledge on the effect of external drivers such as rainfall intensity and surface slope on the wash-off prediction. In this study, a more physically realistic “structure” is added to the original exponential wash-off model (OEM) by replacing the invariant parameters with functions of rainfall intensity and catchment surface slope, so that the model can better represent catchment and rainfall conditions without the need of lookup table and interpolation/extrapolation. In the proposed new exponential model (NEM), two such functions are introduced. One function describes the maximum fraction of the initial load that can be washed off by a rainfall event for a given slope and the other function describes the wash-off rate during a rainfall event for a given slope. The parameters of these functions are estimated using data collected from a series of laboratory experiments carried out using an artificial rainfall generator, a 1 m2 bituminous road surface and a continuous wash-off measuring system. These experimental data contain high temporal resolution measurements of wash-off fractions for combinations of five rainfall intensities ranging from 33-155 mm/hr and three catchment slopes ranging from 2-8 %. Bayesian inference, which allows the incorporation of prior knowledge, is implemented to estimate parameter values. Explicitly accounting for model bias and measurement errors, a likelihood function representative of the wash-off process is formulated, and the uncertainty in the prediction of the NEM is quantified. The results of this study show: 1) even when OEM is calibrated for every experimental condition, NEM’s performance, with parameter values defined by functions, is comparable to OEM. 2) Verification indices for estimates of uncertainty associated with NEM suggest that the error model used in this study is able to capture the uncertainty well.