There has been an increasingly well-documented, rapid rise in tobacco production over the last couple of decades in Mazowe, Zimbabwe, despite growing public health concerns about lung cancer and nicotine’s addictive capacities in the wealthier countries of the West – even affecting the South African market. This has been accompanied by a shift away from its production almost completely on large-scale farms towards predominantly small-scale farms. To date, less consideration has been given to the implications of climate change for tobacco production. Given the hopes that it can make a serious contribution to poverty reduction and food security, it is of increasing importance to understand these implications, to identify the most relevant and/or effective adaptation options and to assess the viability of their successful adoption. This paper presents a fine-grained, qualitative bottom-up analysis of the implications for commercial tobacco production of climate change impacts in Zimbabwe.