The first case of COVID-19 in Nigeria was reported on 27 February 2020. By 30 March 2020, Nigeria had recorded 131 confirmed cases and two deaths. To mitigate the impending health crisis, the Nigerian Government quickly commenced a series of COVID-19 lockdowns across states in Nigeria on 30 March 2020. These lockdowns lasted for three months before a gradual relaxation began on 1 July 2021. However, infection and death cases in the country increased substantially during the months of substantial relaxation of restrictions between October 2020 and March 2021. This paper presents the results of the rapid assessment study in Nigeria between July 2020 and February 2021, which sought to document and understand the differential impacts of the COVID-19 pandemic on agricultural commercialisation, food and nutrition security, employment, poverty, and well-being in rural households.