The semi-arid drylands of central Tanzania have been characterised by low and erratic rainfall coupled with high evapotranspiration. Up until now, farmers of these local dryland farming systems have been able to cope with these climate conditions. However, climate change has led to new weather patterns that overwhelm traditional dryland farming practices and re-shape farmers’ commercialisation pathways. This paper explored the pathways in which smallholder farmers in Singida region in Tanzania engage with markets and commercialise in the face of climate change. The paper also examined how farm-level decisions on commercial crops and the commercialisation pathways they are part of, affect current and future resilience to climate change. Climate resilient commercialisation of smallholder dryland agriculture remains the centrepiece of inclusive sustainable development.