Vaccination against COVID-19 has become a vital public health tool for significantly reducing COVID-19 mortality and morbidity during the pandemic, and is a critical issue of economic and health justice for the world’s informally-employed workers. This Policy Insights assesses the extent of worker vaccination, based on data from the second round of the COVID-19 Crisis and the Informal Economy Study – a longitudinal, mixed methods global study involving thousands of street vendors, home-based workers, waste pickers, domestic workers and other workers in informal employment.