Thesis completed in partial fulfillment of the requirements for the Alfred University Honors Program.Thesis completed in partial fulfillment of the requirements for the Alfred University Honors Program.45S5 is a bioactive glass that has recently shown promise as a bone tissue scaffold material. In order to be used in this manner, the glass must be sintered. Studies have shown that the sintering behavior of a number of materials is affected by particle size. However, the effect of bioactive glass particle size on sintering behavior had, to this point, not been studied at in any depth. The purpose of this research, then, was to determine the effects of particle size on the sintering of 45S5. Results suggest that particle size does affect the sintering behavior of 45S5, and that there is likely an interaction effect between particle size and crystallinity that led to the 53-63_m 45S5 having the lowest sintering temperature.