| dc.creator |
Islinger, M |
|
| dc.creator |
Voelkl, A |
|
| dc.creator |
Fahimi, HD |
|
| dc.creator |
Schrader, M |
|
| dc.date |
2018-09-10T15:12:30Z |
|
| dc.date |
2018-09-15 |
|
| dc.date.accessioned |
2022-05-27T00:49:15Z |
|
| dc.date.available |
2022-05-27T00:49:15Z |
|
| dc.identifier |
Published online 15 September 2018 |
|
| dc.identifier |
10.1007/s00418-018-1722-5 |
|
| dc.identifier |
http://hdl.handle.net/10871/33969 |
|
| dc.identifier |
0948-6143 |
|
| dc.identifier |
Histochemistry and Cell Biology |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/241159 |
|
| dc.description |
This is the final version of the article. Available from Springer Verlag via the DOI in this record. |
|
| dc.description |
Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g.
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular
redox balance. Peroxisomal dysfunction has been linked to severe metabolic disorders in
man, but peroxisomes are now also recognised as protective organelles with a wider
significance in human health and potential impact on a large number of globally important
human diseases such as neurodegeneration, obesity, cancer, and age-related disorders.
Therefore, the interest in peroxisomes and their physiological functions has significantly
increased in recent years. In this review, we intend to highlight recent discoveries,
advancements and trends in peroxisome research, and present an update as well as a
continuation of two former review articles addressing the unsolved mysteries of this
astonishing organelle. We summarise novel findings on the biological functions of
peroxisomes, their biogenesis, formation, membrane dynamics and division, as well as on
peroxisome-organelle contacts and cooperation. Furthermore, novel peroxisomal proteins and
machineries at the peroxisomal membrane are discussed. Finally, we address recent findings
on the role of peroxisomes in the brain, in neurological disorders, and in the development of
cancer. |
|
| dc.description |
This work was supported by the Biotechnology and Biological Sciences Research Council (BB/K006231/1,
BB/N01541X/1) and MRC CiC 08135, University of Exeter (to M.S.). M.I. is supported by
the German Research Foundation (DFG grant 397476530) and MEAMEDMA
Anschubförderung, Medical Faculty Mannheim, University of Heidelberg. |
|
| dc.language |
en |
|
| dc.publisher |
Springer Verlag / Society for Histochemistry |
|
| dc.rights |
© The Author(s) 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
|
| dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
|
| dc.subject |
ACBD5 |
|
| dc.subject |
Alzheimer |
|
| dc.subject |
Cancer |
|
| dc.subject |
Hearing loss |
|
| dc.subject |
Membrane Contact Sites |
|
| dc.subject |
Motility |
|
| dc.subject |
Multiple Sclerosis |
|
| dc.subject |
Organelle biogenesis |
|
| dc.subject |
Organelle division |
|
| dc.subject |
Organelle dynamics |
|
| dc.subject |
Parkinson |
|
| dc.subject |
Peroxin |
|
| dc.subject |
Peroxisome |
|
| dc.title |
The peroxisome: an update on mysteries 2.0 |
|
| dc.type |
Article |
|