| dc.contributor |
Division of Cardiology; Department of Internal Medicine; Xiamen Chang Gung Memorial Hospital; Fujian; China |
|
| dc.contributor |
Department of Plastic Surgery; University Hospital of South Manchester; Manchester; UK |
|
| dc.contributor |
Nursing Department; Basic Science; Meiho University; Pingtung; Taiwan |
|
| dc.contributor |
Division of Cardiology; Department of Internal Medicine; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; Kaohsiung; Taiwan |
|
| dc.contributor |
Division of Cardiology; Department of Internal Medicine; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; Kaohsiung; Taiwan |
|
| dc.contributor |
Department of Biological Sciences; National Sun Yat-Sen University; Kaohsiung; Taiwan |
|
| dc.contributor |
Center for Translational Research in Biomedical Sciences; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; Kaohsiung; Taiwan |
|
| dc.contributor |
Division of Cardiology; Department of Internal Medicine; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; Kaohsiung; Taiwan |
|
| dc.contributor |
Institute of Molecular Biology; Academia Sinica; Taipei; Taiwan |
|
| dc.contributor |
Division of Cardiology; Department of Internal Medicine; Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine; Kaohsiung; Taiwan |
|
| dc.contributor |
Department of Emergency Medicine; E-DA Hospital; I-Shou University; Kaohsiung; Taiwan |
|
| dc.contributor |
Department of Biological Science and Technology; National Pingtung University of Science and Technology; Pingtung; Taiwan |
|
| dc.creator |
Yip, H-K |
|
| dc.creator |
Chang, Y-C |
|
| dc.creator |
Wallace, Christopher G |
|
| dc.creator |
Chang, L-T |
|
| dc.creator |
Tsai, T-H |
|
| dc.creator |
Chen, Y-L |
|
| dc.creator |
Chang, H-W |
|
| dc.creator |
Leu, S |
|
| dc.creator |
Zhen, Y-Y |
|
| dc.creator |
Tsai, C-Y |
|
| dc.creator |
Yeh, K-H |
|
| dc.creator |
Sun, C-K |
|
| dc.creator |
Yen, C-H |
|
| dc.date |
2017-01-04T15:41:18Z |
|
| dc.date |
2017-01-04T15:41:18Z |
|
| dc.date |
2013-03 |
|
| dc.date.accessioned |
2023-02-17T19:47:58Z |
|
| dc.date.available |
2023-02-17T19:47:58Z |
|
| dc.identifier |
Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury 2013, 54 (2):207 Journal of Pineal Research |
|
| dc.identifier |
07423098 |
|
| dc.identifier |
10.1111/jpi.12020 |
|
| dc.identifier |
http://hdl.handle.net/11287/620125 |
|
| dc.identifier |
Journal of Pineal Research |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/241996 |
|
| dc.description |
This study investigated whether melatonin-treated adipose-derived mesenchymal stem cells (ADMSC) offered superior protection against acute lung ischemia-reperfusion (IR) injury. Adult male Sprague-Dawley rats (n = 30) were randomized equally into five groups: sham controls, lung IR-saline, lung IR-melatonin, lung IR-melatonin-normal ADMSC, and lung IR-melatonin-apoptotic ADMSC. Arterial oxygen saturation was lowest in lung IR-saline; lower in lung IR-melatonin than sham controls, lung IR-melatonin-normal ADMSC, and lung IR-melatonin-apoptotic ADMSC; lower in lung IR-melatonin-normal ADMSC than sham controls and lung IR-melatonin-apoptotic ADMSC; lower in lung IR-melatonin-apoptotic ADMSC than sham controls (P < 0.0001 in each case). Right ventricular systolic blood pressure (RVSBP) showed a reversed pattern among all groups (all P < 0.0001). Changes in histological scoring of lung parenchymal damage and CD68+ cells showed a similar pattern compared with RVSBP in all groups (all P < 0.001). Changes in inflammatory protein expressions such as VCAM-1, ICAM-1, oxidative stress, TNF-α, NF-κB, PDGF, and angiotensin II receptor, and changes in apoptotic protein expressions of cleaved caspase 3 and PARP, and mitochondrial Bax, displayed identical patterns compared with RVSBP in all groups (all P < 0.001). Numbers of antioxidant (GR+, GPx+, NQO-1+) and endothelial cell biomarkers (CD31+ and vWF+) were lower in sham controls, lung IR-saline, and lung IR-melatonin than lung IR-melatonin-normal ADMSC and lung IR-melatonin-apoptotic ADMSC, and lower in lung IR-melatonin-normal ADMSC than lung IR-melatonin-apoptotic ADMSC (P < 0.001 in each case). In conclusion, when the animals were treated with melatonin, the apoptotic ADMSC were superior to normal ADMSC for protection of lung from acute IR injury. |
|
| dc.language |
en |
|
| dc.publisher |
Wiley |
|
| dc.relation |
http://doi.wiley.com/10.1111/jpi.12020 |
|
| dc.rights |
Archived with thanks to Journal of Pineal Research |
|
| dc.subject |
Wessex Classification Subject Headings::Respiratory medicine |
|
| dc.title |
Melatonin treatment improves adipose-derived mesenchymal stem cell therapy for acute lung ischemia-reperfusion injury |
|
| dc.type |
Journal Article |
|
| dc.type |
Research Support, Non-U.S. Gov't |
|
| dc.type |
Published |
|