| dc.creator |
Grant, Aaron |
|
| dc.creator |
Vinogradov, Elena |
|
| dc.creator |
Wang, Xiaoen |
|
| dc.creator |
Lenkinski, Robert E. |
|
| dc.creator |
Alsop, David |
|
| dc.date |
2022-07-19T16:34:38Z |
|
| dc.date |
2011-09 |
|
| dc.date |
2022-07-19T16:34:38Z |
|
| dc.date.accessioned |
2023-02-17T19:58:14Z |
|
| dc.date.available |
2023-02-17T19:58:14Z |
|
| dc.identifier |
Grant, Aaron, Elena Vinogradov, Xiaoen Wang, Robert E. Lenkinski, David Alsop. "Perfusion Imaging With a Freely Diffusible Hyperpolarized Contrast Agent." Magnetic Resonance in Medicine 66, no. 3 (2011): 746-755. DOI: 10.1002/mrm.22860 |
|
| dc.identifier |
0740-3194 |
|
| dc.identifier |
1522-2594 |
|
| dc.identifier |
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372652 |
|
| dc.identifier |
10.1002/mrm.22860 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/242069 |
|
| dc.description |
Contrast agents that can diffuse freely into or within tissue have numerous attractive features for perfusion imaging. Here we present preliminary data illustrating the suitability of hyperpolarized 13C labeled 2-methylpropan-2-ol (also known as dimethylethanol, tertiary butyl alcohol and tert-butanol) as a freely diffusible contrast agent for magnetic resonance perfusion imaging. Dynamic 13C images acquired in rat brain with a balanced steady-state free precession (bSSFP) sequence following administration of hyperpolarized 2-methylpropan-2-ol show that this agent can be imaged with 2–4s temporal resolution, 2mm slice thickness, and 700 micron in-plane resolution while retaining adequate signal-to-noise ratio. 13C relaxation measurements on 2-methylpropan-2-ol in blood at 9.4T yield T1=46±4s and T2=0.55±0.03s. In the rat brain at 4.7T, analysis of the temporal dynamics of the bSSFP image intensity in tissue and venous blood indicate that 2-methylpropan-2-ol has a T2 of roughly 2–4s and a T1 of 43±24s. In addition, the images indicate that 2-methylpropan-2-ol is freely diffusible in brain and hence has a long residence time in tissue; this in turn makes it possible to image the agent continuously for tens of seconds. These characteristics show that 2-methylpropan-2-ol is a promising agent for robust and quantitative perfusion imaging in the brain and body. |
|
| dc.description |
Accepted Manuscript |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
Wiley |
|
| dc.relation |
doi:10.1002/mrm.22860 |
|
| dc.relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156294/ |
|
| dc.relation |
Magnetic Resonance in Medicine |
|
| dc.source |
Magn. Reson. Med. |
|
| dc.subject |
Research Subject Categories::MEDICINE::Physiology and pharmacology::Radiological research::Radiology |
|
| dc.title |
Perfusion Imaging With a Freely Diffusible Hyperpolarized Contrast Agent |
|
| dc.title |
Freely Diffusible Hyperpolarized Contrast Agent |
|
| dc.type |
Journal Article |
|