Sangam: A Confluence of Knowledge Streams

Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo

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dc.contributor Massachusetts Institute of Technology. Department of Biology
dc.creator Chew, Marvin
dc.creator Ye, Weijian
dc.creator Omelianczyk, Radoslaw Igor
dc.creator Pasaje, Charisse Flerida
dc.creator Hoo, Regina
dc.creator Chen, Qingfeng
dc.creator Niles, Jacquin C
dc.creator Chen, Jianzhu
dc.creator Preiser, Peter
dc.date 2022-12-07T16:11:56Z
dc.date 2022-12-07T16:11:56Z
dc.date 2022
dc.date 2022-12-07T16:09:15Z
dc.date.accessioned 2023-02-17T20:08:56Z
dc.date.available 2023-02-17T20:08:56Z
dc.identifier https://hdl.handle.net/1721.1/146779
dc.identifier Chew, Marvin, Ye, Weijian, Omelianczyk, Radoslaw Igor, Pasaje, Charisse Flerida, Hoo, Regina et al. 2022. "Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo." Nature Communications, 13 (1).
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/242129
dc.description <jats:title>Abstract</jats:title><jats:p><jats:italic>Plasmodium falciparum</jats:italic> has developed extensive mechanisms to evade host immune clearance. Currently, most of our understanding is based on in vitro studies of individual parasite variant surface antigens and how this relates to the processes in vivo is not well-understood. Here, we have used a humanized mouse model to identify parasite factors important for in vivo growth. We show that upregulation of the specific PfEMP1, VAR2CSA, provides the parasite with protection from macrophage phagocytosis and clearance in the humanized mice. Furthermore, parasites adapted to thrive in the humanized mice show reduced NK cell-mediated killing through interaction with the immune inhibitory receptor, LILRB1. Taken together, these findings reveal new insights into the molecular and cellular mechanisms that the parasite utilizes to coordinate immune escape in vivo. Identification and targeting of these specific parasite variant surface antigens crucial for immune evasion provides a unique approach for therapy.</jats:p>
dc.format application/pdf
dc.language en
dc.publisher Springer Science and Business Media LLC
dc.relation 10.1038/S41467-022-31741-2
dc.relation Nature Communications
dc.rights Creative Commons Attribution 4.0 International license
dc.rights https://creativecommons.org/licenses/by/4.0/
dc.source Nature
dc.title Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo
dc.type Article
dc.type http://purl.org/eprint/type/JournalArticle


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