| dc.contributor |
Buchwald, Stephen L. |
|
| dc.contributor |
Massachusetts Institute of Technology. Department of Chemistry |
|
| dc.creator |
Feng, Sheng |
|
| dc.date |
2022-08-29T16:21:45Z |
|
| dc.date |
2022-08-29T16:21:45Z |
|
| dc.date |
2022-05 |
|
| dc.date |
2022-06-08T13:04:36.615Z |
|
| dc.date.accessioned |
2023-02-17T20:11:51Z |
|
| dc.date.available |
2023-02-17T20:11:51Z |
|
| dc.identifier |
https://hdl.handle.net/1721.1/144930 |
|
| dc.identifier |
0000-0001-8781-9681 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/242167 |
|
| dc.description |
The work described in this dissertation focuses on developing copper(I) hydride (CuH)-catalyzed enantioselective hydrofunctionalization reactions of olefins. The first chapter highlights a method on CuH-catalyzed asymmetric hydroamination of strained trisubstituted alkenes, including cyclobutenes and cyclopropenes. The second chapter presents an approach for accessing enantioenriched α-quaternary carboxylic acids, through CuH-catalyzed hydrocarboxylation of allenes. The third chapter demonstrates the enantioselective hydrocarbamoylation of alkenes enable by dual CuH and Pd catalysis. |
|
| dc.description |
Ph.D. |
|
| dc.format |
application/pdf |
|
| dc.publisher |
Massachusetts Institute of Technology |
|
| dc.rights |
In Copyright - Educational Use Permitted |
|
| dc.rights |
Copyright MIT |
|
| dc.rights |
http://rightsstatements.org/page/InC-EDU/1.0/ |
|
| dc.title |
Development of Copper(I) Hydride-Catalyzed Asymmetric Olefin Hydrofunctionalization Reactions |
|
| dc.type |
Thesis |
|