Sangam: A Confluence of Knowledge Streams

Active control of arousal by a locus coeruleus GABAergic circuit

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dc.contributor Picower Institute for Learning and Memory
dc.contributor Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.creator Breton-Provencher, Vincent
dc.creator Sur, Mriganka
dc.date 2022-06-24T18:00:03Z
dc.date 2021-10-27T20:34:54Z
dc.date 2022-06-24T18:00:03Z
dc.date 2019
dc.date 2019-10-04T11:58:16Z
dc.date.accessioned 2023-02-17T20:19:05Z
dc.date.available 2023-02-17T20:19:05Z
dc.identifier https://hdl.handle.net/1721.1/136330.2
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/242526
dc.description © 2019, The Author(The Author(s), under exclusive licence to Springer Nature America, Inc. Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition. However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we reveal a local population of GABAergic neurons (LC-GABA) capable of modulating LC-NA activity and arousal. Retrograde tracing shows that inputs to LC-GABA and LC-NA neurons arise from similar regions, though a few regions provide differential inputs to one subtype over the other. Recordings in the locus coeruleus demonstrate two modes of LC-GABA responses whereby spiking is either correlated or broadly anticorrelated with LC-NA responses, reflecting anatomically similar and functionally coincident inputs, or differential and non-coincident inputs, to LC-NA and LC-GABA neurons. Coincident inputs control the gain of LC-NA-mediated arousal responses, whereas non-coincident inputs, such as from the prefrontal cortex to the locus coeruleus, alter global arousal levels. These findings demonstrate distinct modes by which an inhibitory locus coeruleus circuit regulates arousal in the brain.
dc.format application/octet-stream
dc.language en
dc.publisher Springer Nature
dc.relation 10.1038/S41593-018-0305-Z
dc.relation Nature Neuroscience
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.source PMC
dc.title Active control of arousal by a locus coeruleus GABAergic circuit
dc.type Article
dc.type http://purl.org/eprint/type/JournalArticle


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