| dc.contributor |
Alzheimer's Research UK |
|
| dc.contributor |
Bernabeu, Elena |
|
| dc.creator |
Bernabeu, Elena |
|
| dc.creator |
McCartney, Daniel L. |
|
| dc.creator |
Gadd, Danni A. |
|
| dc.creator |
Hillary, Robert F. |
|
| dc.creator |
Lu, Ake T. |
|
| dc.creator |
Murphy, Lee |
|
| dc.creator |
Wrobel, Nicola |
|
| dc.creator |
Campbell, Archie |
|
| dc.creator |
Harris, Sara E. |
|
| dc.creator |
Liewald, David |
|
| dc.creator |
Hayward, Caroline |
|
| dc.creator |
Porteous, David J. |
|
| dc.creator |
Sudlow, Cathie |
|
| dc.creator |
Cox, Simon R. |
|
| dc.creator |
Evans, Kathy L. |
|
| dc.creator |
Horvath, Steve |
|
| dc.creator |
McIntosh, Andrew M. |
|
| dc.creator |
Robinson, Matthew R. |
|
| dc.creator |
Vallejos, Catalina A. |
|
| dc.creator |
Marioni, Riccardo E. |
|
| dc.date |
2022-12-21T10:50:19Z |
|
| dc.date |
2022-12-21T10:50:19Z |
|
| dc.date.accessioned |
2023-02-17T20:36:31Z |
|
| dc.date.available |
2023-02-17T20:36:31Z |
|
| dc.identifier |
Bernabeu, Elena; McCartney, Daniel L.; Gadd, Danni A.; Hillary, Robert F.; Lu, Ake T.; Murphy, Lee; Wrobel, Nicola; Campbell, Archie; Harris, Sara E.; Liewald, David; Hayward, Caroline; Porteous, David J.; Sudlow, Cathie; Cox, Simon R.; Evans, Kathy L.; Horvath, Steve; McIntosh, Andrew M.; Robinson, Matthew R.; Vallejos, Catalina A.; Marioni, Riccardo E.. (2022). cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival, [dataset]. University of Edinburgh. College of Medicine & Veterinary Medicine. Institute of Genetics and Cancer. Centre for Genomic & Experimental Medicine (CGEM). https://doi.org/10.7488/ds/3792. |
|
| dc.identifier |
https://hdl.handle.net/10283/4781 |
|
| dc.identifier |
https://doi.org/10.7488/ds/3792 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/242873 |
|
| dc.description |
These datasets correspond to the manuscript “Refining epigenetic prediction of chronological and biological age“. Here, we include the summary statistics for an epigenome-wide association study (EWAS) of age, considering both CpG (linear) and CpG^2 (quadratic) associations, as well as for an EWAS of survival (using a fixed effects Cox Proportional Hazards Model; results for a mixed effects model to account for relatedness included in Supplementary Table 4 of manuscript). Also included are goodness of fit F-test results comparing models accounting and not accounting for a quadratic CpG association, as well as mean and SD of CpG M-values in the Generation Scotland cohort. Further methodological details, including quality control steps, software used, and covariates adjusted for, are described in the accompanying manuscript. Analyses were conducted using the Generation Scotland cohort (N = 18,413). |
|
| dc.format |
text/markdown |
|
| dc.format |
text/tab-separated-values |
|
| dc.format |
text/tab-separated-values |
|
| dc.format |
text/tab-separated-values |
|
| dc.format |
text/tab-separated-values |
|
| dc.format |
text/tab-separated-values |
|
| dc.language |
eng |
|
| dc.publisher |
University of Edinburgh. College of Medicine & Veterinary Medicine. Institute of Genetics and Cancer. Centre for Genomic & Experimental Medicine (CGEM) |
|
| dc.relation |
https://www.biorxiv.org/content/10.1101/2022.09.08.507115v1 |
|
| dc.relation |
https://datashare.ed.ac.uk/handle/10283/4496 |
|
| dc.rights |
Creative Commons Attribution 4.0 International Public License |
|
| dc.subject |
EWAS |
|
| dc.subject |
epigenome wide association study |
|
| dc.subject |
age prediction |
|
| dc.subject |
chronological age |
|
| dc.subject |
biological age |
|
| dc.subject |
summary statistics |
|
| dc.subject |
Biological Sciences::Human Genetics |
|
| dc.title |
cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival |
|
| dc.type |
dataset |
|
| dc.coverage |
UK |
|
| dc.coverage |
UNITED KINGDOM |
|