| dc.contributor |
European Commission |
|
| dc.contributor |
Shi, Ting |
|
| dc.creator |
Shi, Ting |
|
| dc.date |
2019-03-29T10:51:44Z |
|
| dc.date |
2019-04-01T04:15:07Z |
|
| dc.date.accessioned |
2023-02-17T20:52:56Z |
|
| dc.date.available |
2023-02-17T20:52:56Z |
|
| dc.identifier |
Shi, Ting. (2019). Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis, 1996-2018 [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2519. |
|
| dc.identifier |
https://hdl.handle.net/10283/3286 |
|
| dc.identifier |
https://doi.org/10.7488/ds/2519 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/244064 |
|
| dc.description |
Respiratory syncytial virus-associated acute respiratory infection (RSV-ARI) constitutes a substantial disease burden in older adults aged ≥65 years. We aimed to identify all studies worldwide investigating the disease burden of RSV-ARI in this population. We estimated the community incidence, hospitalization rate, and in-hospital case-fatality ratio (hCFR) of RSV-ARI in older adults, stratified by industrialized and developing regions, using data from a systematic review of studies published between January 1996 and April 2018 and 8 unpublished population-based studies. We applied these rate estimates to population estimates for 2015 to calculate the global and regional burdens in older adults with RSV-ARI in the community and in hospitals for that year. We estimated the number of in-hospital deaths due to RSV-ARI by combining hCFR data with hospital admission estimates from hospital-based studies. In 2015, there were about 1.5 million episodes (95% confidence interval [CI], .3 million-6.9 million) of RSV-ARI in older adults in industrialized countries (data for developing countries were missing), and of these, approximately 14.5% (214 000 episodes; 95% CI, 100 000-459 000) were admitted to hospitals. The global number of hospital admissions for RSV-ARI in older adults was estimated at 336 000 hospitalizations (uncertainty range [UR], 186 000-614 000). We further estimated about 14 000 in-hospital deaths (UR, 5000-50 000) related to RSV-ARI globally. The hospital admission rate and hCFR were higher for those aged ≥65 years than for those aged 50-64 years. The disease burden of RSV-ARI among older adults is substantial, with limited data from developing countries. Appropriate prevention and management strategies are needed to reduce this burden. |
|
| dc.format |
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
|
| dc.language |
eng |
|
| dc.publisher |
University of Edinburgh |
|
| dc.relation |
https://www.ncbi.nlm.nih.gov/pubmed/30880339 |
|
| dc.relation |
Ting Shi, A. Denouel, A.K. Tietjen, I. Campbell, E. Moran, X. Li, H. Campbell, C. Demont, B.O. Nyawanda, H.Y. Chu, S.K. Stoszek, A. Krishnan, P. Openshaw, A.R. Falsey, Harish Nair; RESCEU Investigators . Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis. J Infect Dis. 2019 Mar 18. pii: jiz059. doi: 10.1093/infdis/jiz059. [Epub ahead of print] |
|
| dc.rights |
Creative Commons Attribution 4.0 International Public License |
|
| dc.subject |
RSV |
|
| dc.subject |
Medicine and Dentistry |
|
| dc.title |
Global disease burden estimates of respiratory syncytial virus associated with acute respiratory infections in older adults in 2015: A systematic review and meta-analysis |
|
| dc.type |
dataset |
|
| dc.coverage |
Global |
|
| dc.coverage |
start=1996-01; end=2018-04; scheme=W3C-DTF |
|