Data from Wigmore et al "Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP". The Pharmacogenomics Journal 20, 329–341 (2020) DOI:10.1038/s41397-019-0067-3 This dataset consists of two sets of GWAS summary statistics: - case-control analysis of treatment resistance phenotype in the Generation Scotland and GENDEP samples (inverse variance weighted meta-analysis). Cases = 358, Controls = 3855. - quantitative stages of resistance phenotype in Generation Scotland. N = 3452.File: TRD_meta.Wigmore2020.txt.gz Description: Meta-analysis of Generation Scotland and GENDEP Columns: - CHR: chromosome - SNP: marker RSID - BP: base-pair position - A1: effect allele - A2: non-effect allele - Freq1: average frequency of A1 - FreqSE: standard error of frequency - logOR: effect of A1 as log Odds Ratio - logOR_SE: standard error of the effect - P: p-value - Direction: direction of effect from each study (order: GENDEP, GenScot) - HetISq, HetChiSq, HetDf, HetPVal: heterogeneity statistics File: TRD_Stages.Wigmore2020.txt.gz Description: Stage of resistance in Generation Scotland Columns: - CHR: chromsome - SNP: marker RSID - BP: base-pair position - A1: effect allele - A2: non-effect allele - Freq: frequency of A1 - beta: effect of A1 - se: standard error of effect - P: p-value