Sangam: A Confluence of Knowledge Streams

Data and code for: High fidelity fibre-based physiological sensing deep in tissue

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dc.contributor EPSRC - Engineering and Physical Sciences Research Council
dc.contributor Tanner, Michael G
dc.creator Tanner, Michael G
dc.date 2019-05-13T09:14:21Z
dc.date 2019-05-13T09:14:21Z
dc.date.accessioned 2023-02-17T20:53:28Z
dc.date.available 2023-02-17T20:53:28Z
dc.identifier Tanner, Michael G. (2019). Data and code for: High fidelity fibre-based physiological sensing deep in tissue, [dataset]. University of Edinburgh. https://doi.org/10.7488/ds/2546.
dc.identifier https://hdl.handle.net/10283/3325
dc.identifier https://doi.org/10.7488/ds/2546
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/244117
dc.description Physiological sensing deep in tissue, remains a clinical challenge. Here a flexible miniaturised sensing optrode providing a platform to perform minimally invasive in vivo in situ measurements is reported. Silica microspheres covalently coupled with a high density of ratiometrically configured fluorophores were deposited into etched pits on the distal end of a 150 µm diameter multicore optical fibre. With this platform, photonic measurements of pH and oxygen concentration with high precision in the distal alveolar space of the lung are reported. We demonstrated the phenomenon that high-density deposition of carboxyfluorescein covalently coupled to silica microspheres shows an inverse shift in fluorescence in response to varying pH. This platform delivered fast and accurate measurements (± 0.02 pH units and ± 0.6 mg/L of oxygen), near instantaneous response time and a flexible architecture for addition of multiple sensors.
dc.format application/zip
dc.format text/plain
dc.language eng
dc.publisher University of Edinburgh
dc.relation https://doi.org/10.1038/s41598-019-44077-7
dc.relation "High fidelity fibre-based physiological sensing deep in tissue" Tushar R. Choudhary, Michael G. Tanner, Alicia Megia-Fernandez, Kerrianne Harrington, Harry A. Wood, Adam Marshall, Patricia Zhu, Sunay V. Chankeshwara, Debaditya Choudhury, Graham Monro, Muhammed Ucuncu, Fei Yu, Rory R. Duncan, Robert R. Thomson, Kevin Dhaliwal & Mark Bradley Scientific Reports 9, Article number: 7713 (2019). DOI: 10.1038/s41598-019-44077-7
dc.rights Creative Commons Attribution 4.0 International Public License
dc.subject Physical Sciences
dc.title Data and code for: High fidelity fibre-based physiological sensing deep in tissue
dc.type dataset


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