The data are whole-cell patch-clamp recordings from neurons in the medial entorhinal cortex of adult mice. The data for each neuron is a series of voltage responses to current steps or ramps injected through the recording electrode.There are two .tar.gz archive files. One contains stellate cell data and the other contains calbindin cell data. Each file has a similar folder structure when unzipped. The original data was recorded with Axograph and is in the folder 'multi_data'. The folder structure is '/multidata/slice/cell', where slice and cell are names specific to each experiment / recording. The electrophysiology data here is in .axgd format. To open .axgd files you can either use Axograph (available commerically from https://axograph.com/) or Neuromatic (http://www.neuromatic.thinkrandom.com/) which requires IGORpro (available commercially from (https://www.wavemetrics.com/). It should also be possible to open the data using the axographio Python package (https://pypi.org/project/axographio/) but we haven’t tested this. Most 'cell' level folders also contain an image of the slice in .jpg format. The electrophysiology data is also provided in hdf5 format in the folder name 'Database'. These files end in '.h5'. The folders also contain code to build the .h5 files from the .axgd files and then to automatically extract the parameters used for further analyses. This code should be sufficient to replicate the data processing. We plan to separately document and make this code available via our Github site (https://github.com/MattNolanLab).