This book is Open Access under a CC BY licence. This book constitutes the proceedings of the 22nd International Conference on Fundamental Approaches to Software Engineering, FASE 2019, which took place in Prague, Czech Republic in April 2019, held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2019. The 24 papers presented in this volume were carefully reviewed and selected from 94 submissions. The papers are organized in topical sections named: software verification; model-driven development and model transformation; software evolution and requirements engineering; specification, design, and implementation of particular classes of systems; and software testing.