Sangam: A Confluence of Knowledge Streams

Sex differences in the associations between L-arginine pathway metabolites, skeletal muscle mass and function, and their responses to resistance exercise, in old age

Show simple item record

dc.creator Da Boit, Mariasole
dc.creator Tommasi, Sara
dc.creator Elliot, David
dc.creator Zinellu, Angelo
dc.creator Sotgia, Salvatore
dc.creator Sibson, Rachael
dc.creator Meakin, Judith R.
dc.creator Aspden, Richard M.
dc.creator Carru, Ciriaco
dc.creator Mangoni, Arduino A.
dc.creator Gray, Stuart R.
dc.date 2017-08-10T15:57:00Z
dc.date 2017-08-10T15:57:00Z
dc.date 2017-09-02
dc.date 2017-07-06
dc.date.accessioned 2023-02-22T17:04:27Z
dc.date.available 2023-02-22T17:04:27Z
dc.identifier Da Boit, M. et al. (2017) Sex differences in the associations between L-arginine pathway metabolites, skeletal muscle mass and function, and their responses to resistance exercise, in old age. Journal of Nutrition, Health and Aging
dc.identifier http://hdl.handle.net/2086/14412
dc.identifier https://doi.org/10.1007/s12603-017-0964-6
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/254417
dc.description The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
dc.description Objectives The current study was designed to explore the associations between L-arginine metabolites and muscle mass and function in old age, which are largely unknown. Design The study used a randomised, double-blind, placebo-controlled design. Setting The study was carried out in a laboratory setting. Participants 50 healthy older adults [median age 70 years (IQR 67-73); 27 males]. Intervention Participants undertook an 18-week resistance exercise program, and a nutritional intervention (fish oil vs. placebo). Measurements Serum homoarginine, ornithine, citrulline, asymmetric dimethylarginine (ADMA), NG-monomethyl-L-arginine (L-NMMA), and symmetric dimethylarginine (SDMA), maximal voluntary contraction (MVC) and isokinetic torque of the knee extensors at 30° s-1 (MIT), muscle cross sectional area (MCSA) and quality (MQ) were measured at baseline and after the intervention. Results No significant exercise-induced changes were observed in metabolite concentrations. There were significant sex differences in the associations between metabolites and muscle parameters. After adjusting for age, glomerular filtration rate and fish oil intervention, citrulline (P=0.002) and ornithine (P=0.022) were negatively associated with MCSA at baseline in males but not females. However, baseline citrulline was negatively correlated with exercise-induced changes in MVC (P=0.043) and MQ (P=0.026) amongst females. Furthermore, amongst males, baseline homoarginine was positively associated with exercise-induced changes in MVC (P=0.026), ADMA was negatively associated with changes in MIT (P=0.026), L-NMMA (p=0.048) and ornithine (P<0.001) were both positively associated with changes in MCSA, and ornithine was negatively associated with changes in MQ (P=0.039). Conclusion Therefore, barring citrulline, there are significant sex differences in the associations between L-arginine metabolites and muscle mass and function in healthy older adults. These metabolites might enhance sarcopenia risk stratification, and the success of exercise programs, in old age.
dc.format application/pdf
dc.language en
dc.publisher Springer
dc.subject L-arginine
dc.subject skeletal muscle
dc.subject resistance exercise
dc.subject old age
dc.title Sex differences in the associations between L-arginine pathway metabolites, skeletal muscle mass and function, and their responses to resistance exercise, in old age
dc.type Article


Files in this item

Files Size Format View
Manuscript_Accepted version.pdf 89.77Kb application/pdf View/Open

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse