Wireless and mobile technologies are gradually enabling the provision of innovative information services within almost all environments. This study explores the adoption of ubiquitous museum information systems that can significantly enhance and enrich the museum visit. We draw on traditional IS adoption theories and theories from Museum Studies to develop our theoretical model which is empirically tested through a survey addressed to museum visitors (n=118). Model hypotheses are tested through Partial Least Squares modelling. The results show that Performance Expectancy and Personal Innovativeness still represent the core predictors toward the adoption of museum information systems. However, we also report on the predictive strength of two context-related factors, Invisibility and Interaction, which appear to play a particular role toward the formulation of favourable user perceptions. The paper concludes with implications on the design of museum information systems and specific suggestions for future research.