Three experiments were designed to measure the effects of enzyme supplementation on growth performance, ileal digestibility and fecal digestibility on dry matter, protein, gross energy, and amino acids as well as excretion of odor compounds. In experiment 1, an enzyme cocktail containing the activities of protease, cellulase, pentosanase, α-galactosidase, and amylase (Allzyme® Vegpro, Alltech Inc., Nicholasville, KY) was incorporated in a corn-soybean meal diet for growing pigs. The results showed that addition of the enzyme did not improve fecal digestibility, ileal digestibility, or amino acid digestibility when either chromic oxide or acid insoluble ash were used as markers. In experiment 2, the same enzyme cocktail was incorporated in corn-soybean meal diets with or without 30% soy hulls for growing pigs. Results showed that addition of the enzyme to corn-soybean meal based diets alone or with 30% added soy hulls did not improve the apparent ileal or fecal digestibilities of growing pigs. In experiment 3, the same enzyme cocktail was incorporated into a corn-soybean meal based diet with 20% soy hulls and compared to typical corn-soybean diet as well as a corn-soybean meal based diet with 20% soy hulls without enzyme. There were no significant effects of the enzyme added to the corn⁄soybean meal/soy hull diet of pigs on growth performance, carcass characteristics, ammonia emission or odor. However, the addition of enzyme improved gross energy digestibility and improved also improved the digestibilities of Ca, P, Mg, K, Fe, Zn, Cu, and Mn. Overall, our data indicate that addition of enzymes to higher fiber diets show promising results in increasing the digestibility of these feedstuffs.