| dc.creator |
De, Subhajyoti |
|
| dc.creator |
Michor, Franziska |
|
| dc.date |
2019-09-30T11:55:44Z |
|
| dc.date |
2011 |
|
| dc.date |
2019-09-30T11:55:44Z |
|
| dc.date.accessioned |
2022-05-18T11:03:46Z |
|
| dc.date.available |
2022-05-18T11:03:46Z |
|
| dc.identifier |
De, Subhajyoti, and Franziska Michor. 2011. “DNA Secondary Structures and Epigenetic Determinants of Cancer Genome Evolution.” Nature Structural & Molecular Biology 18 (8): 950–55. https://doi.org/10.1038/nsmb.2089. |
|
| dc.identifier |
1474-7596 |
|
| dc.identifier |
1474-760X |
|
| dc.identifier |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41426757 |
|
| dc.identifier |
10.1038/nsmb.2089 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/26582 |
|
| dc.description |
An unstable genome is a hallmark of many cancers. It is unclear, however, whether some mutagenic features driving somatic alterations in cancer are encoded in the genome sequence and whether they can operate in a tissue-specific manner. We performed a genome-wide analysis of 663,446 DNA breakpoints associated with somatic copy-number alterations (SCNAs) from 2,792 cancer samples classified into 26 cancer types. Many SCNA breakpoints are spatially clustered in cancer genomes. We observed a significant enrichment for G-quadruplex sequences (G4s) in the vicinity of SCNA breakpoints and established that SCNAs show a strand bias consistent with G4-mediated structural alterations. Notably, abnormal hypomethylation near G4s-rich regions is a common signature for many SCNA breakpoint hotspots. We propose a mechanistic hypothesis that abnormal hypomethylation in genomic regions enriched for G4s acts as a mutagenic factor driving tissue-specific mutational landscapes in cancer. |
|
| dc.description |
Accepted Manuscript |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
BMC |
|
| dc.relation |
Genome Biology |
|
| dc.title |
DNA secondary structures and epigenetic determinants of cancer genome evolution |
|
| dc.type |
Journal Article |
|