| dc.creator |
Pucci, Ferdinando |
|
| dc.creator |
Garris, Christopher |
|
| dc.creator |
Lai, Charles |
|
| dc.creator |
Newton, Andita |
|
| dc.creator |
Pfirschke, Christina |
|
| dc.creator |
Engblom, Camilla |
|
| dc.creator |
Alvarez, David |
|
| dc.creator |
Sprachman, Melissa |
|
| dc.creator |
Evavold, Charles |
|
| dc.creator |
Magnuson, Angela |
|
| dc.creator |
von Andrian, Ulrich H. |
|
| dc.creator |
Glatz, Katharina |
|
| dc.creator |
Breakefield, Xandra |
|
| dc.creator |
Mempel, Thorsten |
|
| dc.creator |
Weissleder, Ralph |
|
| dc.creator |
Pittet, Mikael |
|
| dc.date |
2019-09-21T03:35:56Z |
|
| dc.date |
2016 |
|
| dc.date |
2019-09-21T03:35:56Z |
|
| dc.date.accessioned |
2022-05-18T11:04:07Z |
|
| dc.date.available |
2022-05-18T11:04:07Z |
|
| dc.identifier |
Pucci, F., C. Garris, C. P. Lai, A. Newton, C. Pfirschke, C. Engblom, D. Alvarez, et al. 2016. “SCS Macrophages Suppress Melanoma by Restricting Tumor-Derived Vesicle-B Cell Interactions.” Science 352 (6282): 242–46. https://doi.org/10.1126/science.aaf1328. |
|
| dc.identifier |
0036-8075 |
|
| dc.identifier |
1095-9203 |
|
| dc.identifier |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41384248 |
|
| dc.identifier |
10.1126/science.aaf1328 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/26612 |
|
| dc.description |
Tumor-derived extracellular vesicles (tEVs) are important signals in tumor-host cell communication, yet it remains unclear how endogenously produced tEVs affect the host in different areas of the body. We combined imaging and genetic analysis to track melanoma-derived vesicles at organismal, cellular, and molecular scales to show that endogenous tEVs efficiently disseminate via lymphatics and preferentially bind subcapsular sinus (SCS) CD169(+) macrophages in tumor-draining lymph nodes (tdLNs) in mice and humans. The CD169(+) macrophage layer physically blocks tEVdissemination but is undermined during tumor progression and by therapeutic agents. A disrupted SCS macrophage barrier enables tEVs to enter the lymph node cortex, interact with B cells, and foster tumor-promoting humoral immunity. Thus, CD169(+) macrophages may act as tumor suppressors by containing tEV spread and ensuing cancer-enhancing immunity. |
|
| dc.description |
Accepted Manuscript |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
American Association for the Advancement of Science |
|
| dc.relation |
Science |
|
| dc.title |
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions |
|
| dc.type |
Journal Article |
|