Sangam: A Confluence of Knowledge Streams

Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment

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dc.contributor Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
dc.contributor McGovern Institute for Brain Research at MIT
dc.contributor Vander Weele, Caitlin Miya
dc.contributor Yao, Junmei
dc.contributor Saenz, Christopher
dc.contributor dos Santos Correia, Susana Mar
dc.contributor Goosens, Ki Ann
dc.creator Vander Weele, Caitlin Miya
dc.creator Saenz, Christopher
dc.creator Yao, Junmei
dc.creator dos Santos Correia, Susana Mar
dc.creator Goosens, Ki Ann
dc.date 2014-06-19T20:17:01Z
dc.date 2014-06-19T20:17:01Z
dc.date 2013-06
dc.date.accessioned 2023-03-01T18:11:09Z
dc.date.available 2023-03-01T18:11:09Z
dc.identifier 1662-5153
dc.identifier http://hdl.handle.net/1721.1/88040
dc.identifier Vander Weele, Caitlin M., Christopher Saenz, Junmei Yao, Susana S. Correia, and Ki A. Goosens. “Restoration of Hippocampal Growth Hormone Reverses Stress-Induced Hippocampal Impairment.” Front. Behav. Neurosci. 7 (2013).
dc.identifier https://orcid.org/0000-0002-8269-2615
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/279073
dc.description Though growth hormone (GH) is synthesized by hippocampal neurons, where its expression is influenced by stress exposure, its function is poorly characterized. Here, we show that a regimen of chronic stress that impairs hippocampal function in rats also leads to a profound decrease in hippocampal GH levels. Restoration of hippocampal GH in the dorsal hippocampus via viral-mediated gene transfer completely reversed stress-related impairment of two hippocampus-dependent behavioral tasks, auditory trace fear conditioning, and contextual fear conditioning, without affecting hippocampal function in unstressed control rats. GH overexpression reversed stress-induced decrements in both fear acquisition and long-term fear memory. These results suggest that loss of hippocampal GH contributes to hippocampal dysfunction following prolonged stress and demonstrate that restoring hippocampal GH levels following stress can promote stress resilience.
dc.description National Institute of Mental Health (U.S.) (NIMH (R01 MH084966))
dc.description United States. Army Research Office
dc.description United States. Defense Advanced Research Projects Agency (grant W911NF-10-1-0059)
dc.format application/pdf
dc.language en_US
dc.publisher Frontiers Research Foundation
dc.relation http://dx.doi.org/10.3389/fnbeh.2013.00066
dc.relation Frontiers in Behavioral Neuroscience
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.source Frontiers Research Foundation
dc.title Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment
dc.type Article
dc.type http://purl.org/eprint/type/JournalArticle


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