| dc.contributor |
Harvard University--MIT Division of Health Sciences and Technology |
|
| dc.creator |
Akeju, Oluwaseun |
|
| dc.creator |
Brown, Emery Neal |
|
| dc.date |
2020-08-07T19:27:15Z |
|
| dc.date |
2020-08-07T19:27:15Z |
|
| dc.date |
2017-05 |
|
| dc.date |
2019-09-30T12:36:30Z |
|
| dc.date.accessioned |
2023-03-01T18:11:10Z |
|
| dc.date.available |
2023-03-01T18:11:10Z |
|
| dc.identifier |
0959-4388 |
|
| dc.identifier |
1873-6882 |
|
| dc.identifier |
https://hdl.handle.net/1721.1/126517 |
|
| dc.identifier |
Akeju, Oluwaseun and Emery N Brown. "Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep." Current Opinion in Neurobiology, 44 (June 2017): 178-185 © 2017 Elsevier Ltd |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/279074 |
|
| dc.description |
General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class produces distinct oscillatory dynamics that can be related to the circuit mechanisms of drug action. Sleep is a naturally occurring state of decreased arousal that is essential for normal health. Physiological measurements (electrooculogram, electromyogram) and neural oscillatory (electroencephalogram) dynamics are used to empirically characterize sleep into rapid eye movement sleep and the three stages of non-rapid eye movement sleep. In this review, we discuss the differences between anesthesia- and sleep-induced altered states from the perspective of neural oscillations. |
|
| dc.description |
National Institute of Health (U.S.) (Grant TR01 GM-104948) |
|
| dc.description |
National Institute of Health (U.S.) (Grant P01 GM-118629) |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Elsevier BV |
|
| dc.relation |
http://dx.doi.org/10.1016/j.conb.2017.04.011 |
|
| dc.relation |
Current Opinion in Neurobiology |
|
| dc.rights |
Creative Commons Attribution-NonCommercial-NoDerivs License |
|
| dc.rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
| dc.source |
PMC |
|
| dc.title |
Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep |
|
| dc.type |
Article |
|
| dc.type |
http://purl.org/eprint/type/JournalArticle |
|