| dc.contributor |
Harvard University--MIT Division of Health Sciences and Technology |
|
| dc.contributor |
Sasisekharan, Ram |
|
| dc.contributor |
Raman, Rahul |
|
| dc.contributor |
Sasisekharan, Ram |
|
| dc.contributor |
Bachelet, Ido |
|
| dc.creator |
Raman, Rahul |
|
| dc.creator |
Sasisekharan, Ram |
|
| dc.creator |
Bachelet, Ido |
|
| dc.creator |
Bulmera, Mark S. |
|
| dc.creator |
Rosengaus, Rebeca B. |
|
| dc.date |
2010-03-12T19:45:53Z |
|
| dc.date |
2010-03-12T19:45:53Z |
|
| dc.date |
2009-04 |
|
| dc.date |
2009-01 |
|
| dc.date.accessioned |
2023-03-01T18:12:04Z |
|
| dc.date.available |
2023-03-01T18:12:04Z |
|
| dc.identifier |
1091-6490 |
|
| dc.identifier |
0027-8424 |
|
| dc.identifier |
http://hdl.handle.net/1721.1/52551 |
|
| dc.identifier |
Bulmer, Mark S et al. “Targeting an antimicrobial effector function in insect immunity as a pest control strategy.” Proceedings of the National Academy of Sciences 106.31 (2009): 12652-12657. © 2010 National Academy of Sciences |
|
| dc.identifier |
https://orcid.org/0000-0002-2085-7840 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/279131 |
|
| dc.description |
Insect pests such as termites cause damages to crops and man-made structures estimated at over $30 billion per year, imposing a global challenge for the human economy. Here, we report a strategy for compromising insect immunity that might lead to the development of nontoxic, sustainable pest control methods. Gram-negative bacteria binding proteins (GNBPs) are critical for sensing pathogenic infection and triggering effector responses. We report that termite GNBP-2 (tGNBP-2) shows β(1,3)-glucanase effector activity previously unknown in animal immunity and is a pleiotropic pattern recognition receptor and an antimicrobial effector protein. Termites incorporate this protein into the nest building material, where it functions as a nest-embedded sensor that cleaves and releases pathogenic components, priming termites for improved antimicrobial defense. By means of rational design, we present an inexpensive, nontoxic small molecule glycomimetic that blocks tGNBP-2, thus exposing termites in vivo to accelerated infection and death from specific and opportunistic pathogens. Such a molecule, introduced into building materials and agricultural methods, could protect valuable assets from insect pests. |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
United States National Academy of Sciences |
|
| dc.relation |
http://dx.doi.org/10.1073/pnas.0904063106 |
|
| dc.relation |
Proceedings of the National Academy of Sciences of the United States of America |
|
| dc.rights |
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. |
|
| dc.source |
PNAS |
|
| dc.title |
Targeting an antimicrobial effector function in insect immunity as a pest control strategy |
|
| dc.type |
Article |
|
| dc.type |
http://purl.org/eprint/type/JournalArticle |
|