| dc.contributor |
Massachusetts Institute of Technology. Department of Chemical Engineering |
|
| dc.creator |
Gérardy, Romaric |
|
| dc.creator |
Nambiar, Anirudh MK |
|
| dc.creator |
Hart, Travis |
|
| dc.creator |
Mahesh, Prajwal T |
|
| dc.creator |
Jensen, Klavs F |
|
| dc.date |
2022-10-06T15:49:36Z |
|
| dc.date |
2022-10-06T15:49:36Z |
|
| dc.date |
2022-08 |
|
| dc.date |
2022-10-06T15:44:13Z |
|
| dc.date.accessioned |
2023-03-01T18:12:29Z |
|
| dc.date.available |
2023-03-01T18:12:29Z |
|
| dc.identifier |
https://hdl.handle.net/1721.1/145714 |
|
| dc.identifier |
Gérardy, Romaric, Nambiar, Anirudh MK, Hart, Travis, Mahesh, Prajwal T and Jensen, Klavs F. 2022. "Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform." Chemistry – A European Journal, 28 (43). |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/279157 |
|
| dc.description |
The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization. |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Wiley |
|
| dc.relation |
10.1002/chem.202201385 |
|
| dc.relation |
Chemistry – A European Journal |
|
| dc.rights |
Creative Commons Attribution NonCommercial License 4.0 |
|
| dc.rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
|
| dc.source |
Wiley |
|
| dc.title |
Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform |
|
| dc.type |
Article |
|
| dc.type |
http://purl.org/eprint/type/JournalArticle |
|