| dc.contributor |
Keele, N. Bradley. |
|
| dc.contributor |
Baylor University. Dept. of Psychology and Neuroscience. |
|
| dc.contributor |
Psychology and Neuroscience. |
|
| dc.creator |
Lasher, Bonnie Ka. |
|
| dc.date |
2009-06-01T19:21:41Z |
|
| dc.date |
2009-06-01T19:21:41Z |
|
| dc.date |
2009-05 |
|
| dc.date |
2009-06-01T19:21:41Z |
|
| dc.date.accessioned |
2022-05-18T12:01:36Z |
|
| dc.date.available |
2022-05-18T12:01:36Z |
|
| dc.identifier |
http://hdl.handle.net/2104/5302 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/28006 |
|
| dc.description |
Includes bibliographical references (p. 44-55). |
|
| dc.description |
The lateral nucleus of the amygdala (LA) plays a key role in learned fear and anxiety, while dysfunctional LA circuitry is implicated in fear and anxiety psychopathologies. The LA is under inhibitory modulation and prone to hyperexcitation with inhibitory release. This hyperexcitation can result in enhanced fear and anxiety behaviors. Serotonin (5-HT) is also implicated in fear and anxiety disorders, plus, 5-HTergic innervation of the LA is inhibitory. Reduction in 5-HTergic control may induce hyperexcitation, suggesting a 5-HTergic mechanism in fear and anxiety disorders. This study accesses the effects of reduced 5-HT in the LA on conditioned fear behavior responses by lesioning 5-HT fibers with 5,7-dihydroxytryptamine and measuring fear potentiated startle. Seizure susceptibility after lowered 5-HT was also examined. Low-5-HT in the LA enhanced fear potentiated startle. This study implies that a reduction in 5-HT in the LA results in abnormal fear and anxiety possibly due to hyperexcitation. |
|
| dc.description |
by Bonnie Ka Lasher. |
|
| dc.description |
M.A. |
|
| dc.format |
ix, 55 p. : ill., photos. |
|
| dc.format |
158242 bytes |
|
| dc.format |
724376 bytes |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.rights |
Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission. |
|
| dc.rights |
Worldwide access |
|
| dc.subject |
Amydaloid body -- Psychophysiology. |
|
| dc.subject |
Serotonin -- Antagonists -- Physiological effect. |
|
| dc.subject |
Fear -- Physiological aspects. |
|
| dc.subject |
Anxiety -- Physiological aspects. |
|
| dc.subject |
Startle reaction. |
|
| dc.subject |
Rats -- Behavior. |
|
| dc.title |
5,7-dihydroxytryptamine lesions of the rat amygdala increase learned fear behavior. |
|
| dc.title |
Five,seven-dihydroxytryptamine lesions of the rat amygdala increase learned fear behavior. |
|
| dc.type |
Thesis |
|