Our changing climate will likely have serious implications on agriculture production through its effects on food and feed crop yield and quality, forage and livestock production, and pest dynamics, including troublesome weed control. With regards to weeds, climatic variables control many plant physiology functions that impact flowering, fruiting, and seed dormancy; therefore, an altered climate can result in a weed species composition shift within agro-ecosystems. Weed species will likely adapt to a changing climate due to their high phenotypic plasticity and vast genetic diversity. Higher temperatures and CO<sub>2</sub> concentrations, and altered moisture conditions, not only affect the growth of weeds, but also impact the effectiveness of herbicides in controlling weeds. Therefore, weed biology, growth characteristics, and their management are predicted to be affected greatly by changing climatic conditions. This manuscript attempted to compile the available information on general principles of weed response to changing climatic conditions, including elevated CO<sub>2</sub> and temperature under diverse rainfall patterns and drought. Likewise, we have also attempted to highlight the effect of soil moisture dynamics on the efficacy of various herbicides under diverse agro-ecosystems.
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