Sangam: A Confluence of Knowledge Streams

Genetic diversity of Plasmodium vivax in clinical isolates from Bangladesh

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dc.contributor Biochemistry
dc.creator Kibria, Mohammad G.
dc.creator Elahi, Rubayet
dc.creator Mohon, Abu N.
dc.creator Khan, Wasif A.
dc.creator Haque, Rashidul
dc.creator Alam, Mohammad S.
dc.date 2015-07-31T16:41:01Z
dc.date 2015-07-31T16:41:01Z
dc.date 2015-07-11
dc.date 2015-07-31T16:41:01Z
dc.date.accessioned 2023-03-01T18:53:20Z
dc.date.available 2023-03-01T18:53:20Z
dc.identifier Malaria Journal. 2015 Jul 11;14(1):267
dc.identifier http://hdl.handle.net/10919/55028
dc.identifier https://doi.org/10.1186/s12936-015-0790-4
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281714
dc.description Background Plasmodium vivax is the second most prevalent human malaria parasite in Bangladesh; however, there are no data of its genetic diversity. Several molecular markers are available where Pvcsp, Pvmsp 1 and Pvmsp 3α are most commonly used for P. vivax genotyping studies. The aim of the study was to investigate the population structure of P. vivax in Bangladesh. Methods A total of 102 P. vivax-positive blood samples were collected from different malaria-endemic areas in Bangladesh and subsequently analysed for those three genotyping markers. Nested PCR was performed for diagnosis and genotyping analysis followed by PCR–RFLP to detect genetic diversity using Pvcsp, Pvmsp 1 and Pvmsp 3α markers. Results Analysis of Pvcsp showed that the VK210 repeat type was highly prevalent (64.7%, 66/102) compared to VK247 (35.3%, 36/102), although the prevalence of VK247 was higher than other Southeast Asian countries. Analysis of these three genes revealed a diverse, circulating population of P. vivax where a total of ten, 56 and 35 distinct genotypes were detected for Pvcsp, Pvmsp 1 and Pvmsp 3α, respectively. Conclusion This genotyping observation of P. vivax is the first report from Bangladesh and will provide valuable information for establishing the genotyping methods and circulating genetic variants of these three markers available in Bangladesh.
dc.description Published version
dc.format application/pdf
dc.format application/pdf
dc.language en_US
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.rights Kibria et al.
dc.title Genetic diversity of Plasmodium vivax in clinical isolates from Bangladesh
dc.title Malaria Journal
dc.type Article - Refereed
dc.type Text


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