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A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics

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dc.creator Pieknik, J. R.
dc.creator Bertke, Andrea S.
dc.creator Tang, S.
dc.creator Krause, P. R.
dc.date 2018-09-15T13:51:07Z
dc.date 2018-09-15T13:51:07Z
dc.date 2018-05-01
dc.date.accessioned 2023-03-01T18:53:36Z
dc.date.available 2023-03-01T18:53:36Z
dc.identifier Pieknik, J.R.; Bertke, A.S.; Tang, S.; Krause, P.R. A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics. Viruses 2018, 10, 246.
dc.identifier 1999-4915
dc.identifier http://hdl.handle.net/10919/85023
dc.identifier https://doi.org/10.3390/v10050246
dc.identifier 10
dc.identifier 5
dc.identifier Bertke, AS [0000-0002-8941-8010]
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281743
dc.description Fluorescent herpes simplex viruses (HSV) are invaluable tools for localizing virus in cells, permitting visualization of capsid trafficking and enhancing neuroanatomical research. Fluorescent viruses can also be used to study virus kinetics and reactivation in vivo. Such studies would be facilitated by fluorescent herpes simplex virus recombinants that exhibit wild-type kinetics of replication and reactivation and that are genetically stable. We engineered an HSV-2 strain expressing the fluorescent mNeonGreen protein as a fusion with the VP26 capsid protein. This virus has normal replication and in vivo recurrence phenotypes, providing an essential improved tool for further study of HSV-2 infection.
dc.description Published version
dc.format ? - ? (13) page(s)
dc.format application/pdf
dc.format application/pdf
dc.language en
dc.publisher MDPI
dc.relation http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000435198000031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.subject Virology
dc.subject HSV-2
dc.subject reactivation
dc.subject guinea pig
dc.subject fluorescent HSV-2
dc.subject mNeonGreen
dc.subject vaginal infection model
dc.subject HERPES-SIMPLEX-VIRUS
dc.subject GREEN FLUORESCENT PROTEIN
dc.subject IN-VIVO
dc.subject REPLICATION
dc.subject INFECTION
dc.subject LOCALIZATION
dc.subject TRANSPORT
dc.subject ENVELOPE
dc.subject TEGUMENT
dc.subject GANGLIA
dc.title A VP26-mNeonGreen Capsid Fusion HSV-2 Mutant Reactivates from Viral Latency in the Guinea Pig Genital Model with Normal Kinetics
dc.title Viruses
dc.type Article - Refereed
dc.type Text


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