| dc.contributor |
Fralin Biomedical Research Institute |
|
| dc.creator |
MacDonald, Tobey J. |
|
| dc.creator |
Liu, Jingbo |
|
| dc.creator |
Yu, Bing |
|
| dc.creator |
Malhotra, Anshu |
|
| dc.creator |
Munson, Jennifer M. |
|
| dc.creator |
Park, Jaekeun C. |
|
| dc.creator |
Wang, Kenty |
|
| dc.creator |
Fei, Baowei |
|
| dc.creator |
Bellamkonda, Ravi |
|
| dc.creator |
Arbiser, Jack |
|
| dc.date |
2021-03-15T11:43:59Z |
|
| dc.date |
2021-03-15T11:43:59Z |
|
| dc.date |
2021-03-11 |
|
| dc.date |
2021-03-12T14:40:49Z |
|
| dc.date.accessioned |
2023-03-01T18:53:38Z |
|
| dc.date.available |
2023-03-01T18:53:38Z |
|
| dc.identifier |
MacDonald, T.J.; Liu, J.; Yu, B.; Malhotra, A.; Munson, J.; Park, J.C.; Wang, K.; Fei, B.; Bellamkonda, R.; Arbiser, J. Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo. Cancers 2021, 13, 1220. |
|
| dc.identifier |
http://hdl.handle.net/10919/102717 |
|
| dc.identifier |
https://doi.org/10.3390/cancers13061220 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/281747 |
|
| dc.description |
Sonic hedgehog subtype of medulloblastoma (SHH MB) with metastasis or specific clinical or molecular alteration shas a poor prognosis and current therapy results in long-term cognitive impairment in the majority of survivors. Thus, a great need exists for new targeted therapeutic approaches to more effectively treat SHH MB in children. Imipramine blue (IB), a novel molecule with anti-tumor properties, inhibits the NADPH oxidase (NOX) family of enzymes, which are critical for SHH MB survival and treatment resistance. In this study, IB was encapsulated within a liposome to form a liposomal nanoparticle, Liposome-IB (Lipo-IB). This complex has the ability to cross the blood–brain barrier and be preferentially taken up by tumor cells within the brain. We demonstrated in vitro that Lipo-IB treatment caused a dose-dependent decrease in SHH MB cell viability and migration. Short-term administration of single agent Lipo-IB treatment of SHH MB in vivo significantly inhibited tumor growth, reduced the tumor volume, including a complete tumor response, and improved survival compared to control treated mice, without any observable toxicity. We conclude that Lipo-IB is a potential novel nanoparticle-based therapeutic for the treatment of SHH MB that warrants further preclinical safety and efficacy testing for development towards clinical investigation. |
|
| dc.description |
Published version |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
MDPI |
|
| dc.rights |
Creative Commons Attribution 4.0 International |
|
| dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
|
| dc.subject |
medulloblastoma |
|
| dc.subject |
reactive oxygen |
|
| dc.subject |
Nox4 |
|
| dc.subject |
sonic hedghog |
|
| dc.title |
Liposome-Imipramine Blue Inhibits Sonic Hedgehog Medulloblastoma In Vivo |
|
| dc.title |
Cancers |
|
| dc.type |
Article - Refereed |
|
| dc.type |
Text |
|
| dc.type |
StillImage |
|