Sangam: A Confluence of Knowledge Streams

A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse

Show simple item record

dc.contributor Human Nutrition, Foods, and Exercise
dc.contributor Population Health Sciences
dc.creator Jarrah, Abdul Salam
dc.creator Castiglione, Filippo
dc.creator Evans, Nicholas P.
dc.creator Grange, Robert W.
dc.creator Laubenbacher, Reinhard C.
dc.date 2017-09-18T09:41:43Z
dc.date 2017-09-18T09:41:43Z
dc.date 2014-06-11
dc.date 2017-09-18T09:41:43Z
dc.date.accessioned 2023-03-01T18:54:14Z
dc.date.available 2023-03-01T18:54:14Z
dc.identifier Abdul Salam Jarrah, Filippo Castiglione, Nicholas P. Evans, Robert W. Grange, and Reinhard Laubenbacher, “A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse,” BioMed Research International, vol. 2014, Article ID 871810, 11 pages, 2014. doi:10.1155/2014/871810
dc.identifier http://hdl.handle.net/10919/78960
dc.identifier https://doi.org/10.1155/2014/871810
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281807
dc.description Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood. The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD. During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process. For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described. In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes. Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared.
dc.description Published version
dc.format application/pdf
dc.format text/xml
dc.format application/pdf
dc.language en
dc.publisher Hindawi
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.rights Copyright © 2014 Abdul Salam Jarrah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.title A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse
dc.title BioMed Research International
dc.type Article - Refereed
dc.type Text


Files in this item

Files Size Format View
BMRI.2014.871810.pdf 4.896Mb application/pdf View/Open
BMRI.2014.871810.xml 9.176Kb text/xml View/Open

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse