| dc.creator |
Hlucny, Katelyn |
|
| dc.creator |
Alexander, Brenda M. |
|
| dc.creator |
Gerow, Kenneth G. |
|
| dc.creator |
Larson-Meyer, D. Enette |
|
| dc.date |
2021-08-09T16:55:28Z |
|
| dc.date |
2021-08-09T16:55:28Z |
|
| dc.date |
2021-07-23 |
|
| dc.date |
2021-08-06T15:19:04Z |
|
| dc.date.accessioned |
2023-03-01T18:54:17Z |
|
| dc.date.available |
2023-03-01T18:54:17Z |
|
| dc.identifier |
Hlucny, K.; Alexander, B.M.; Gerow, K.; Larson-Meyer, D.E. Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study. Nutrients 2021, 13, 2520. |
|
| dc.identifier |
http://hdl.handle.net/10919/104615 |
|
| dc.identifier |
https://doi.org/10.3390/nu13082520 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/281814 |
|
| dc.description |
Background: The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg). Methods: A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline. Results: UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA (<i>p</i> = 0.001) and RDA to 3× RDA diets (<i>p</i> = 0.04). Serum iodine was different from RDA to 3× RDA (<i>p</i> = 0.006) whereas Tg was not responsive to diet. Baseline UIC was associated with iodine intake from milk (r = 0.688, <i>p</i> = 0.028) and fish/seafood (r = 0.646, <i>p</i> = 0.043). Conclusion: These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status. |
|
| dc.description |
Published version |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
MDPI |
|
| dc.rights |
Creative Commons Attribution 4.0 International |
|
| dc.rights |
http://creativecommons.org/licenses/by/4.0/ |
|
| dc.subject |
iodine status |
|
| dc.subject |
biomarkers |
|
| dc.subject |
validation |
|
| dc.subject |
nutritional exposure |
|
| dc.subject |
dietary biomarkers |
|
| dc.subject |
iodine intake |
|
| dc.subject |
urinary iodine concentration |
|
| dc.subject |
serum iodine |
|
| dc.subject |
thyroglobulin |
|
| dc.subject |
food frequency questionnaire |
|
| dc.subject |
dairy products |
|
| dc.title |
Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study |
|
| dc.title |
Nutrients |
|
| dc.type |
Article - Refereed |
|
| dc.type |
Text |
|