Sangam: A Confluence of Knowledge Streams

Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p− and Snord116m−/p− Mouse Models of Prader–Willi Syndrome

Show simple item record

dc.creator Knott, Brittney
dc.creator Kocher, Matthew A.
dc.creator Paz, Henry A.
dc.creator Hamm, Shelby E.
dc.creator Fink, William
dc.creator Mason, Jordan
dc.creator Grange, Robert W.
dc.creator Wankhade, Umesh D.
dc.creator Good, Deborah J.
dc.date 2022-02-25T13:47:09Z
dc.date 2022-02-25T13:47:09Z
dc.date 2022-02-18
dc.date 2022-02-24T14:49:57Z
dc.date.accessioned 2023-03-01T18:54:43Z
dc.date.available 2023-03-01T18:54:43Z
dc.identifier Knott, B.; Kocher, M.A.; Paz, H.A.; Hamm, S.E.; Fink, W.; Mason, J.; Grange, R.W.; Wankhade, U.D.; Good, D.J. Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p− and Snord116m−/p− Mouse Models of Prader–Willi Syndrome. Nutrients 2022, 14, 860.
dc.identifier http://hdl.handle.net/10919/108860
dc.identifier https://doi.org/10.3390/nu14040860
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281860
dc.description Prader&ndash;Willi Syndrome (PWS) is a human genetic condition that affects up to 1 in 10,000 live births. Affected infants present with hypotonia and developmental delay. Hyperphagia and increasing body weight follow unless drastic calorie restriction is initiated. Recently, our laboratory showed that one of the genes in the deleted locus causative for PWS, <i>Snord116</i>, maintains increased expression of hypothalamic <i>Nhlh2</i>, a basic helix&ndash;loop&ndash;helix transcription factor. We have previously also shown that obese mice with a deletion of <i>Nhlh2</i> respond to a conjugated linoleic acid (CLA) diet with weight and fat loss. In this study, we investigated whether mice with a paternal deletion of <i>Snord116</i> (<i>Snord116<sup>m+/p&minus;</sup></i>) would respond similarly. We found that while <i>Snord116<sup>m+/p&minus;</sup></i> mice and mice with a deletion of both <i>Snord116</i> alleles were not significantly obese on a high-fat diet, they did lose body weight and fat on a high-fat/CLA diet, suggesting that the genotype did not interfere with CLA actions. There were no changes in food intake or metabolic rate, and only moderate differences in exercise performance. RNA-seq and microbiome analyses identified hypothalamic mRNAs, and differentially populated gut bacteria, that support future mechanistic analyses. CLA may be useful as a food additive to reduce obesity in humans with PWS.
dc.description Published version
dc.format application/pdf
dc.format application/pdf
dc.language en
dc.publisher MDPI
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.title Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p&minus; and Snord116m&minus;/p&minus; Mouse Models of Prader&ndash;Willi Syndrome
dc.title Nutrients
dc.type Article - Refereed
dc.type Text


Files in this item

Files Size Format View
nutrients-14-00860-v2.pdf 4.310Mb application/pdf View/Open

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse