Sangam: A Confluence of Knowledge Streams

Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review

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dc.contributor Biomedical Sciences and Pathobiology
dc.creator Tang, Kuo-Tung
dc.creator Chen, Hsin-Hua
dc.creator Chen, Tzu-Ting
dc.creator Bracci, Nicole R.
dc.creator Lin, Chi-Chien
dc.date 2021-08-26T18:43:14Z
dc.date 2021-08-26T18:43:14Z
dc.date 2021-08-09
dc.date 2021-08-26T13:26:43Z
dc.date.accessioned 2023-03-01T18:54:57Z
dc.date.available 2023-03-01T18:54:57Z
dc.identifier Tang, K.-T.; Chen, H.-H.; Chen, T.-T.; Bracci, N.R.; Lin, C.-C. Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review. Life 2021, 11, 801.
dc.identifier http://hdl.handle.net/10919/104720
dc.identifier https://doi.org/10.3390/life11080801
dc.identifier.uri http://localhost:8080/xmlui/handle/CUHPOERS/281885
dc.description Antiphospholipid syndrome (APS) is an autoimmune disease characterized by autoreactive B and T cells against β2-glycoprotein I (B2GPI), with vascular thrombosis or obstetrical complications. Dendritic cells (DCs) are crucial in the generation of autoimmunity. Here, we conducted a comprehensive systematic review on the relationship between DC and APS. We performed a literature search of PubMed as of 26 March 2021. A total of 33 articles were extracted. DCs are pivotal in inducing inflammatory responses and orchestrating adaptive immunity. DCs contribute to the local inflammation regarding vascular thrombosis or obstetrical complications. Both B2GPI and antiphospholipid antibodies (aPL) can promote antigen presentation by DCs and the generation or maintenance of autoimmunity. In addition, plasmacytoid DC activation is enhanced by aPL, thereby augmenting the inflammatory response. In line with these findings, DC modulation appears promising as a future treatment for APS. In conclusion, our review indicated the crucial role of DCs in the pathogenesis of APS. Deeper understanding of the complex relationship would help in developing new treatment strategies.
dc.description Published version
dc.format application/pdf
dc.format application/pdf
dc.language en
dc.publisher MDPI
dc.rights Creative Commons Attribution 4.0 International
dc.rights http://creativecommons.org/licenses/by/4.0/
dc.subject antiphospholipid syndrome
dc.subject autoimmunity
dc.subject β2-glycoprotein I
dc.subject dendritic cell
dc.subject immune tolerance
dc.title Dendritic Cells and Antiphospholipid Syndrome: An Updated Systematic Review
dc.title Life
dc.type Article - Refereed
dc.type Text


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