| dc.contributor |
Pinney, Kevin G. |
|
| dc.contributor |
Chemistry. |
|
| dc.contributor |
Honors College. |
|
| dc.creator |
Cody, Andrew |
|
| dc.date |
2013-05-24T20:35:15Z |
|
| dc.date |
2013-05-24T20:35:15Z |
|
| dc.date |
2013 |
|
| dc.date |
2013-05-24 |
|
| dc.date.accessioned |
2022-05-18T12:29:16Z |
|
| dc.date.available |
2022-05-18T12:29:16Z |
|
| dc.identifier |
http://hdl.handle.net/2104/8698 |
|
| dc.identifier.uri |
http://localhost:8080/xmlui/handle/CUHPOERS/31751 |
|
| dc.description |
Metastasis is often the ultimate cause of death among cancer patients. An emerging target in the treatment of metastasis is cathepsin L which facilitates the degradation of the extracellular matrix thereby providing a pathway for the movement of cancer cells to secondary locations in the body from the primary tumor. A variety of potent small-molecule cathepsin L inhibitors bearing the thiosemicarbazone moiety have been discovered through the collaboration of the Pinney Research Group and Trawick Research Group at Baylor University. A compound known as KGP94 is among the more potent inhibitors discovered and has been re-synthesized for further studies. The majority of thiosemicarbazone containing inhibitors of cathepsin L are asymmetrical and prone to isomerization about the imine bond of the thiosemicarbazone functional group. Since isomerization may interfere with the ability of these compounds to inhibit cathespin L, a series of symmetrical thiosemicarbazone analogues was prepared and evaluated as inhibitors of cathepsin L. |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.rights |
Baylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission. |
|
| dc.rights |
Worldwide access. |
|
| dc.rights |
Access changed 8/25/15. |
|
| dc.subject |
Organic synthesis. |
|
| dc.subject |
Cancer. |
|
| dc.subject |
Metastasis. |
|
| dc.title |
Design and Synthesis of Functionalized Thiosemicarbazone Analogues as Potential Anti-metastatic Agents |
|
| dc.type |
Thesis |
|